Gjone H, Stevenson J, Sundet J M, Eilertsen D E
National Centre for Child and Adolescent Psychiatry, University of Oslo, Norway.
Behav Genet. 1996 Jul;26(4):419-26. doi: 10.1007/BF02359486.
The present study addresses the issue of differential heritability with increasing severity of parent-reported internalizing and externalizing behavior problems assessed by the Child Behavior Checklist. The sample includes 526 identical and 389 fraternal same-sexed twin pairs from five national birth cohorts, aged 5-6, 8-9, and 12-15 years. Heritability (h2), common environment (c2), and changes in these parameters as a function of proband score were analyzed by multiple regression models (Cherny et al., 1992). Internalizing and externalizing behavior showed significant heritability. A small increment in h2 and a reduction of c2 with increasing severity of externalizing behavior were independent of sex and age. For internalizing behavior h2 increased and c2 declined with increasing severity for the 5-6 and 8-9 year olds. Logarithmic transformation of scores lowered h2 and increased c2, particularly for externalizing behavior. The changes in heritability with severity were nonsignificant for the transformed variables.
本研究探讨了通过儿童行为量表评估的父母报告的内化和外化行为问题严重程度增加时的差异遗传率问题。样本包括来自五个全国出生队列的526对同卵双胞胎和389对异卵同性双胞胎，年龄分别为5 - 6岁、8 - 9岁和12 - 15岁。通过多元回归模型分析遗传率（h2）、共同环境（c2）以及这些参数随先证者分数的变化（Cherny等人，1992）。内化和外化行为表现出显著的遗传率。随着外化行为严重程度的增加，h2略有增加，c2略有降低，且与性别和年龄无关。对于5 - 6岁和8 - 9岁的儿童，随着内化行为严重程度的增加，h2增加，c2下降。分数的对数转换降低了h2并增加了c2，特别是对于外化行为。对于转换后的变量，遗传率随严重程度的变化不显著。
