Striebel H W, Oelmann T, Spies C, Rieger A, Schwagmeier R
Department of Anesthesiology and Intensive Care Medicine, Benjamin Franklin Medical Center, Free University of Berlin, Germany.
Anesth Analg. 1996 Sep;83(3):548-51. doi: 10.1097/00000539-199609000-00019.
Recently, a new device for patient-controlled intranasal analgesia (PCINA) was described, and a pilot study demonstrated promising results with respect to efficacy and patient satisfaction. The present study compares PCINA with intravenous (IV) patient-controlled analgesia (PCA). Fifty orthopedic patients were prospectively studied over an 8-h period on the first day after surgery. The patients were randomly allocated to PCINA group (n = 25) or to an IV PCA group (n = 25). Pain intensity was evaluated at 30-min intervals using a 101-point numerical rating scale. With respect to initial pain intensity, there was no significant intergroup difference. At the 30- to 480-min measurement points pain intensity in the PCINA group (P < 0.0001) and the IV PCA group (P < 0.0001) was significantly less as compared to the initial value. There was no significant intergroup difference in pain intensity. No patient had problems using the PCINA device. The present study demonstrates, that PCINA provides relief of postoperative pain as effectively as IV PCA.
最近，一种新型的患者自控鼻内镇痛（PCINA）装置被报道，一项初步研究在疗效和患者满意度方面显示出了有前景的结果。本研究将PCINA与静脉注射（IV）患者自控镇痛（PCA）进行比较。五十名骨科患者在术后第一天接受了为期8小时的前瞻性研究。患者被随机分配到PCINA组（n = 25）或IV PCA组（n = 25）。使用101点数字评分量表每隔30分钟评估一次疼痛强度。关于初始疼痛强度，组间没有显著差异。在30至480分钟的测量点，PCINA组（P < 0.0001）和IV PCA组（P < 0.0001）的疼痛强度与初始值相比显著降低。疼痛强度在组间没有显著差异。没有患者在使用PCINA装置时遇到问题。本研究表明，PCINA在缓解术后疼痛方面与IV PCA同样有效。
