Kuljukka T, Vaaranrinta R, Veidebaum T, Sorsa M, Peltonen K
Molecular Dosimetry Group, Finnish Institute of Occupational Health, Helsinki, Finland.
Environ Health Perspect. 1996 May;104 Suppl 3(Suppl 3):539-41. doi: 10.1289/ehp.96104s3539.
The exposure of Estonian cokery workers to polynuclear aromatic hydrocarbons at an oil shale processing plant was assessed by occupational hygiene and biomonitoring measurements. To assess the external dose of exposure to polynuclear aromatic hydrocarbons, pyrene and benzo[a]pyrene concentrations were measured from the breathing zone of workers during a workshift. Skin contamination with pyrene and benzo[a]pyrene was assessed by skin wipe sampling. As a biomarker of exposure to polynuclear aromatic hydrocarbons and as an integral of all possible absorption routes of pyrene, 1-hydroxypyrene concentration was measured from post-shift urine samples. Eighteen percent of the personal air samples exceeded the Finnish threshold limit value of benzol[a]pyrene (10 micrograms/m3). Mean values for benzo[a]pyrene and pyrene were 5.7 micrograms/m3 and 8.1 micrograms/m3, respectively. Based on skin wipe sample analyses, the skin contamination was also obvious. The mean value of benzo[a]pyrene on the samples collected after the shift was 1.2 ng/cm2. In control samples, benzo[a]pyrene was not found. The mean value of urinary 1-hydroxypyrene concentration was 6.0 nmol/mmol creatinine for the exposed workers and 0.5 nmol/mmol creatinine for the controls. This study showed the usefulness of 1-hydroxypyrene as an indicator of internal dose of polynuclear aromatic hydrocarbons. We concluded that the cokery workers at the Kohtla-Järve plant are exposed to high concentrations of polynuclear aromatic compounds.
通过职业卫生和生物监测测量，对爱沙尼亚一家油页岩加工厂的炼焦工人接触多环芳烃的情况进行了评估。为了评估多环芳烃的外部暴露剂量，在一个工作班次期间，从工人的呼吸区域测量了芘和苯并[a]芘的浓度。通过皮肤擦拭采样评估芘和苯并[a]芘的皮肤污染情况。作为多环芳烃暴露的生物标志物以及芘所有可能吸收途径的综合指标，从轮班后的尿液样本中测量了1-羟基芘的浓度。18%的个人空气样本超过了芬兰苯并[a]芘的阈限值（10微克/立方米）。苯并[a]芘和芘的平均值分别为5.7微克/立方米和8.1微克/立方米。根据皮肤擦拭样本分析，皮肤污染也很明显。轮班后采集的样本上苯并[a]芘的平均值为1.2纳克/平方厘米。在对照样本中未发现苯并[a]芘。暴露工人尿液中1-羟基芘浓度的平均值为6.0纳摩尔/毫摩尔肌酐，对照组为0.5纳摩尔/毫摩尔肌酐。这项研究表明1-羟基芘作为多环芳烃内部剂量指标的有用性。我们得出结论，科赫特拉-耶尔韦工厂的炼焦工人接触高浓度的多环芳烃化合物。
