Ogino J, Moore R E, Patterson G M, Smith C D
Department of Chemistry, University of Hawaii at Manoa, Honolulu 96822, USA.
J Nat Prod. 1996 Jun;59(6):581-6. doi: 10.1021/np960178s.
Dendroamide A (1), one of three new bistratamide-type cyclic hexapeptides from the terrestrial blue-green alga (cyanobacterium) Stigonema dendroideum Fremy, exhibits multidrug-resistance reversing activity. The gross structures of the three compounds, dendroamides A-C, were determined by NMR and mass spectral analyses. Their absolute stereochemistries were determined by Marfey and chiral GC/MS analyses of derivatives formed from acid hydrolysis of the intact and ozonized peptides.
树状酰胺A（1）是从陆生蓝绿藻（蓝细菌）树状点形粘球藻中分离得到的三种新型双链酰胺型环六肽之一，具有多药耐药逆转活性。通过核磁共振（NMR）和质谱分析确定了三种化合物——树状酰胺A - C的总体结构。通过对完整肽段和经臭氧处理的肽段酸水解形成的衍生物进行马尔菲法和手性气相色谱/质谱分析，确定了它们的绝对立体化学结构。
