Xu J, Taylor E W, Panhuysen C I, Prenger V L, Koskela R, Kiemeney B, LaBuda M C, Maestri N E, Meyers D A
Johns Hopkins Medical Institutions, Baltimore, Maryland, USA.
Genet Epidemiol. 1995;12(6):825-30. doi: 10.1002/gepi.1370120649.
A two-locus segregation and linkage-analysis approach was used to characterize the genetic control of a complex trait (Q1) and to localize the genes that have detectable effects. The results suggested that a two-locus Mendelian model fit the data significantly better than a one-locus model. The linkage results based on the most parsimonious two-locus model revealed linkage of Q1 to two areas (MG2 and MG3), while there was less evidence for linkage using one-locus models. Results also suggested that the subphenotypes (Q2 and Q3) provided useful information for further analysis of Q1 using two-locus models.
