Raymond J, Kalach N, Bergeret M, Barbet J P, Benhamou P H, Gendrel D, Dupont C
Department of Microbiology, Hôpital Saint Vincent de Paul, Paris, France.
Eur J Clin Microbiol Infect Dis. 1996 May;15(5):415-7. doi: 10.1007/BF01690102.
A serological test for the diagnosis of Helicobacter pylori infection (Cobas Core Roche, IgG, 2nd Generation; Roche, France) was compared with the examination of biopsy samples (culture and histology) obtained after endoscopy in 115 children to assess its value. In 94 children (42 positive and 52 negative), results were concordant. In 10 children a positive serological test was associated with an absence of Helicobacter pylori, while in 11 others a negative serological test was associated with a positive culture. Sensitivity of the test was 79.2% and specificity 83.9%. A relationship between IgG titers and age (r = 0.31, p < 0.05) was found. Serological tests could be useful for the diagnosis of Helicobacter pylori infection, but a negative test result does not rule out infection, particularly in children under 10 years of age.
对115名儿童进行了一项用于诊断幽门螺杆菌感染的血清学检测（Cobas Core Roche，IgG，第二代；罗氏公司，法国），并将其与内镜检查后获取的活检样本（培养和组织学检查）结果进行比较，以评估该血清学检测的价值。在94名儿童中（42名阳性和52名阴性），结果一致。在10名儿童中，血清学检测呈阳性但未检测到幽门螺杆菌，而在另外11名儿童中，血清学检测呈阴性但培养结果为阳性。该检测的敏感性为79.2%，特异性为83.9%。发现IgG滴度与年龄之间存在相关性（r = 0.31，p < 0.05）。血清学检测对幽门螺杆菌感染的诊断可能有用，但检测结果为阴性并不能排除感染，特别是对于10岁以下的儿童。
