Mathiesen L R, Papaevangelou G, Purcell R H, Grammatikopoulos D, Contoyannis P, Wong D
J Clin Microbiol. 1980 Mar;11(3):297-300. doi: 10.1128/jcm.11.3.297-300.1980.
In a 4-month period, 216 cases of acute viral hepatitis were diagnosed in adults at the Infectious Diseases Hospital, Athens, Greece. Twenty-six percent of these were hepatitis B surface antigen negative. A full set of clinical specimens was obtained from 19 of these patients, who were studied in depth for the etiology of their hepatitis. A total of 7 of the 19 patients had serological evidence of hepatitis A virus infection, and 2 had evidence of recent hepatitis B virus infection. The remaining 10 patients lacked evidence of hepatitis A virus, hepatitis B virus, cytomegalovirus, or Epstein-Barr virus infection related to their illness and were classified as having type non-A, non-B hepatitis. Types A and non-A, non-B hepatitis were clinically similar in these adults patients. However, patients with type non-a, non-B hepatitis were, on the average, older and more likely to have received parenteral inoculations during the 6 months before contracting hepatitis. Approximately 76% of the 216 consecutive cases of acute viral hepatitis were probably type B, approximately 10% were probably type A, and approximately 14% were probably type non-A, non-B, although the latter two types may be underestimated because of the possibility of superinfection with these viruses in asymptomatic hepatitis B surface antigen carriers. Thus, all three types of viral hepatitis appear to be important in the etiology of liver disease in Athens, Greece.
在4个月的时间里，希腊雅典传染病医院诊断出216例成人急性病毒性肝炎病例。其中26%的病例乙肝表面抗原呈阴性。从其中19例患者身上获取了全套临床标本，并对他们肝炎的病因进行了深入研究。19例患者中共有7例有甲型肝炎病毒感染的血清学证据，2例有近期乙型肝炎病毒感染的证据。其余10例患者缺乏与疾病相关的甲型肝炎病毒、乙型肝炎病毒、巨细胞病毒或爱泼斯坦-巴尔病毒感染的证据，被归类为非甲非乙型肝炎。甲型和非甲非乙型肝炎在这些成年患者中临床症状相似。然而，非甲非乙型肝炎患者平均年龄较大，且在患肝炎前6个月接受肠道外接种的可能性更大。在这216例连续的急性病毒性肝炎病例中，约76%可能为乙型，约10%可能为甲型，约14%可能为非甲非乙型，不过后两种类型可能因无症状乙肝表面抗原携带者出现这些病毒重叠感染的可能性而被低估。因此，所有这三种类型的病毒性肝炎在希腊雅典肝病的病因中似乎都很重要。
