关于新氨基糖苷类抗生素奈替米星的体外研究。
In vitro studies on netilmicin, a new aminoglycoside antibiotic.
作者信息
Stewart D, Bodey G P, LeBlanc B
出版信息
Antimicrob Agents Chemother. 1977 Jun;11(6):1017-20. doi: 10.1128/AAC.11.6.1017.
Abstract
Netilmicin, a semisynthetic derivative of sisomicin, was tested in vitro against 600 clinical bacterial isolates. At a concentration of 1.56 mug/ml, over 90% of gram-negative bacilli were inhibited. Netilmicin was substantially more active against isolates of Serratia marcescens and Enterobacter spp. than gentamicin, sisomicin, tobramycin, or amikacin. Isolates of Staphylococcus aureus (both penicillin G susceptible and resistant) were quite susceptible to netilmicin. Most isolates of Klebsiella spp. and Serratia spp. and some of the isolates of Pseudomonas aeruginosa that were resistant to gentamicin proved to be susceptible to netilmicin.
摘要
奈替米星是西索米星的半合成衍生物，对600株临床分离细菌进行了体外试验。在浓度为1.56微克/毫升时，超过90%的革兰氏阴性杆菌受到抑制。奈替米星对粘质沙雷氏菌和肠杆菌属菌株的活性明显高于庆大霉素、西索米星、妥布霉素或阿米卡星。金黄色葡萄球菌（对青霉素G敏感和耐药的菌株）对奈替米星相当敏感。大多数克雷伯菌属和沙雷氏菌属菌株以及一些对庆大霉素耐药的铜绿假单胞菌菌株对奈替米星敏感。
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Antimicrob Agents Chemother. 1977 Jun;11(6):1017-20. doi: 10.1128/AAC.11.6.1017.
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本文引用的文献
1
Resistance of gram-negative bacilli to gentamicin.革兰氏阴性杆菌对庆大霉素的耐药性。
J Infect Dis. 1971 Dec;124 Suppl:S264-70. doi: 10.1093/infdis/124.supplement_1.s264.
2
Colonization with gentamicin-resistant Pseudomonas aeruginosa, pyocine type 5, in a burn unit.在一个烧伤病房中出现对庆大霉素耐药的5型绿脓杆菌定植。
J Infect Dis. 1971 Dec;124 Suppl:S18-23. doi: 10.1093/infdis/124.supplement_1.s18.
3
Infections due to gram-negative organisms: an analysis of 860 patients with bacteremia at the University of Minnesota Medical Center, 1958-1966.革兰氏阴性菌感染：对明尼苏达大学医学中心1958年至1966年间860例菌血症患者的分析。
Medicine (Baltimore). 1969 Jul;48(4):307-32. doi: 10.1097/00005792-196907000-00003.
4
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Antimicrob Agents Chemother. 1976 Nov;10(5):827-36. doi: 10.1128/AAC.10.5.827.
5
Comparative activity of netilmicin, gentamicin, amikacin, and tobramycin against Pseudomonas aeruginosa and Enterobacteriaceae.奈替米星、庆大霉素、阿米卡星和妥布霉素对铜绿假单胞菌和肠杆菌科细菌的比较活性。
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6
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