Owen A M, Milner B, Petrides M, Evans A C
Montreal Neurological Institute, McGill University, QC, Canada.
Proc Natl Acad Sci U S A. 1996 Aug 20;93(17):9212-7. doi: 10.1073/pnas.93.17.9212.
Regional cerebral blood flow was measured with positron-emission tomography during two encoding and two retrieval tasks that were designed to compare memory for object features with memory for object locations. Bilateral increases in regional cerebral blood flow were observed in both anterior and posterior regions of inferior temporal cortex and in ventral regions of prestriate cortex, when the condition that required retrieval of object locations was subtracted from the condition that required retrieval of object features. During encoding, these changes were less pronounced and were restricted to the left inferior temporal cortex and right ventral prestriate cortex. In contrast, both encoding and retrieval of object location were associated with bilateral changes in dorsal prestriate and posterior parietal cortex. Finally, the two encoding conditions activated left frontal lobe regions preferentially, whereas the two retrieval conditions activated right frontal lobe regions. These findings confirm that, in human subjects, memory for object features is mediated by a distributed system that includes ventral prestriate cortex and both anterior and posterior regions of the inferior temporal gyrus. In contrast, memory for the locations of objects appears to be mediated by an anatomically distinct system that includes more dorsal regions of prestriate cortex and posterior regions of the parietal lobe.
在两项编码任务和两项检索任务期间，采用正电子发射断层扫描技术测量局部脑血流量，这些任务旨在比较对物体特征的记忆和对物体位置的记忆。当从需要检索物体特征的条件中减去需要检索物体位置的条件时，在颞下回的前部和后部区域以及纹前皮质的腹侧区域均观察到局部脑血流量的双侧增加。在编码过程中，这些变化不太明显，且仅限于左侧颞下回皮质和右侧纹前皮质腹侧。相比之下，物体位置的编码和检索均与纹前皮质背侧和顶叶后部的双侧变化有关。最后，两种编码条件优先激活左额叶区域，而两种检索条件则激活右额叶区域。这些发现证实，在人类受试者中，对物体特征的记忆由一个分布式系统介导，该系统包括纹前皮质腹侧以及颞下回的前部和后部区域。相比之下，对物体位置的记忆似乎由一个在解剖学上不同的系统介导，该系统包括纹前皮质的更多背侧区域和顶叶的后部区域。
