用于诊断急性面神经麻痹患者莱姆病螺旋体感染的免疫球蛋白M免疫印迹法
Immunoglobulin M immunoblot for diagnosis of Borrelia burgdorferi infection in patients with acute facial palsy.
作者信息
Jain V K, Hilton E, Maytal J, Dorante G, Ilowite N T, Sood S K
机构信息
Division of Infectious Diseases, Schneider Children's Hospital, New Hyde Park, New York 11040, USA.
出版信息
J Clin Microbiol. 1996 Aug;34(8):2033-5. doi: 10.1128/jcm.34.8.2033-2035.1996.
Abstract
We used immunoblotting to improve the specificity of the serologic diagnosis of Lyme borreliosis in cases of acute facial palsy. Twelve of 15 patients (80%) with suspected Lyme borreliosis, versus 0 of 10 controls, were positive by immunoglobulin M immunoblotting of acute-phase sera and 3 were negative, including 2 with borderline enzyme immunoassay results. Immunoglobulin M immunoblotting is a useful test to confirm Borrelia burgdorferi infection in patients with acute facial palsy and a positive enzyme immunoassay result.
摘要
我们采用免疫印迹法提高急性面神经麻痹患者莱姆病血清学诊断的特异性。15例疑似莱姆病患者中有12例（80%）急性期血清免疫球蛋白M免疫印迹检测呈阳性，而10例对照者均为阴性，3例呈阴性，其中2例酶免疫测定结果为临界值。免疫球蛋白M免疫印迹法对于确诊急性面神经麻痹且酶免疫测定结果为阳性的患者是否感染伯氏疏螺旋体是一项有用的检测方法。
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Immunoglobulin M immunoblot for diagnosis of Borrelia burgdorferi infection in patients with acute facial palsy.用于诊断急性面神经麻痹患者莱姆病螺旋体感染的免疫球蛋白M免疫印迹法
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本文引用的文献
1
The overdiagnosis of Lyme disease.莱姆病的过度诊断
JAMA. 1993 Apr 14;269(14):1812-6.
2
Epidemiology and clinical manifestations of Lyme borreliosis in childhood. A prospective multicentre study with special regard to neuroborreliosis.儿童莱姆病的流行病学与临床表现。一项特别关注神经莱姆病的前瞻性多中心研究。
Acta Paediatr Suppl. 1993 Feb;386:1-75. doi: 10.1111/j.1651-2227.1993.tb18082.x.
3
Western blotting in the serodiagnosis of Lyme disease.蛋白质免疫印迹法在莱姆病血清学诊断中的应用
J Infect Dis. 1993 Feb;167(2):392-400. doi: 10.1093/infdis/167.2.392.
4
Neurologic manifestations in children with North American Lyme disease.
Neurology. 1993 Dec;43(12):2609-14. doi: 10.1212/wnl.43.12.2609.
5
Interpretation of immunoblot in pediatric Lyme arthritis.儿童莱姆关节炎免疫印迹法的解读
J Rheumatol. 1995 Apr;22(4):758-61.
6
Early disseminated Lyme disease: Lyme meningitis.早期播散性莱姆病：莱姆脑膜炎。
Am J Med. 1995 Apr 24;98(4A):30S-37S; discussion 37S-43S. doi: 10.1016/s0002-9343(99)80042-4.
7
Tick-borne spirochetes as a cause of facial palsy.蜱传螺旋体作为面神经麻痹的一个病因。
Clin Otolaryngol Allied Sci. 1985 Oct;10(5):279-84. doi: 10.1111/j.1365-2273.1985.tb00255.x.
8
Facial paralysis in Lyme disease.莱姆病所致面瘫。
Laryngoscope. 1985 Nov;95(11):1341-5.
9
The triad of neurologic manifestations of Lyme disease: meningitis, cranial neuritis, and radiculoneuritis.莱姆病神经系统表现的三联征：脑膜炎、颅神经炎和神经根神经炎。
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10
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