71株产酸克雷伯菌临床菌株的β-内酰胺酶基因启动子
beta-lactamase gene promoters of 71 clinical strains of Klebsiella oxytoca.
作者信息
Fournier B, Lagrange P H, Philippon A
机构信息
Laboratoire de Microbiologie, Université Paris VII, France.
出版信息
Antimicrob Agents Chemother. 1996 Feb;40(2):460-3. doi: 10.1128/AAC.40.2.460.
Abstract
beta-Lactamase gene promoters of 45 clinical Klebsiella oxytoca isolates resistant to beta-lactams and exhibiting beta-lactamase hyperproduction differed from those in 26 susceptible strains. Direct sequencing revealed one mutation in either the -10 or -35 conserved sequences: a G-to-A transition of the fifth base (67%) or a G-to-T transversion of the first base of the -10 sequence (27%) or a T-to-A transversion in the fourth base in the -35 sequence (4%). One strain carried both the -10 transition and the -35 transversion.
摘要
45株对β-内酰胺类耐药且表现出β-内酰胺酶高产的临床产酸克雷伯菌分离株的β-内酰胺酶基因启动子与26株敏感菌株不同。直接测序显示在-10或-35保守序列中有一个突变：第五个碱基的G到A转换（67%），或-10序列第一个碱基的G到T颠换（27%），或-35序列第四个碱基的T到A颠换（4%）。一株菌同时携带-10转换和-35颠换。
相似文献
1
beta-lactamase gene promoters of 71 clinical strains of Klebsiella oxytoca.71株产酸克雷伯菌临床菌株的β-内酰胺酶基因启动子
Antimicrob Agents Chemother. 1996 Feb;40(2):460-3. doi: 10.1128/AAC.40.2.460.
2
Point mutation in the pribnow box, the molecular basis of beta-lactamase overproduction in Klebsiella oxytoca.肺炎克雷伯菌中β-内酰胺酶过量产生的分子基础——普里布诺框中的点突变
Antimicrob Agents Chemother. 1995 Jun;39(6):1365-8. doi: 10.1128/AAC.39.6.1365.
3
Genetic characterization of resistance to extended-spectrum beta-lactams in Klebsiella oxytoca isolates recovered from patients with septicemia at hospitals in the Stockholm area.从斯德哥尔摩地区医院败血症患者中分离出的产酸克雷伯菌菌株对超广谱β-内酰胺类抗生素耐药性的基因特征分析。
Antimicrob Agents Chemother. 1999 May;43(5):1294-7. doi: 10.1128/AAC.43.5.1294.
4
Strength and regulation of the different promoters for chromosomal beta-lactamases of Klebsiella oxytoca.产酸克雷伯菌染色体β-内酰胺酶不同启动子的强度及调控
Antimicrob Agents Chemother. 1999 Apr;43(4):850-5. doi: 10.1128/AAC.43.4.850.
5
Klebsiella oxytoca: resistance to aztreonam by overproduction of the chromosomally encoded beta-lactamase.产酸克雷伯菌：通过过量产生染色体编码的β-内酰胺酶对氨曲南耐药。
FEMS Microbiol Lett. 1994 Feb 1;116(1):31-6. doi: 10.1111/j.1574-6968.1994.tb06671.x.
6
Chromosomal beta-lactamase genes of Klebsiella oxytoca are divided into two main groups, blaOXY-1 and blaOXY-2.产酸克雷伯菌的染色体β-内酰胺酶基因分为两个主要组，blaOXY-1和blaOXY-2。
Antimicrob Agents Chemother. 1996 Feb;40(2):454-9. doi: 10.1128/AAC.40.2.454.
7
Neonatal intensive care unit outbreak caused by a strain of Klebsiella oxytoca resistant to aztreonam due to overproduction of chromosomal beta-lactamase.由一株因染色体β-内酰胺酶过度产生而对氨曲南耐药的产酸克雷伯菌引起的新生儿重症监护病房暴发。
J Hosp Infect. 2001 Aug;48(4):281-8. doi: 10.1053/jhin.2001.1018.
8
Can results obtained with commercially available MicroScan microdilution panels serve as an indicator of beta-lactamase production among escherichia coli and Klebsiella isolates with hidden resistance to expanded-spectrum cephalosporins and aztreonam?使用市售的MicroScan微量稀释板获得的结果能否作为大肠埃希菌和克雷伯菌分离株中β-内酰胺酶产生的指标，这些分离株对广谱头孢菌素和氨曲南存在隐匿性耐药？
J Clin Microbiol. 1998 Sep;36(9):2575-9. doi: 10.1128/JCM.36.9.2575-2579.1998.
9
Characterization of FOX-3, an AmpC-type plasmid-mediated beta-lactamase from an Italian isolate of Klebsiella oxytoca.FOX-3的特性研究，FOX-3是一种来自意大利产酸克雷伯菌分离株的AmpC型质粒介导的β-内酰胺酶。
Antimicrob Agents Chemother. 1998 Feb;42(2):464-7. doi: 10.1128/AAC.42.2.464.
10
A survey of beta-lactamases from 618 isolates of Klebsiella spp.对618株克雷伯菌属分离株的β-内酰胺酶进行的一项调查
J Antimicrob Chemother. 1993 Jan;31(1):29-35. doi: 10.1093/jac/31.1.29.
引用本文的文献
1
Phylogenetic lineages and antimicrobial resistance determinants of clinical spanning local to global scales.跨越地方到全球范围的临床菌株的系统发育谱系和抗菌药物耐药性决定因素。
Microbiol Spectr. 2023 Sep 7;11(5):e0054923. doi: 10.1128/spectrum.00549-23.
2
Klebsiella oxytoca Complex: Update on Taxonomy, Antimicrobial Resistance, and Virulence.产酸克雷伯菌复合体：分类学、抗菌耐药性和毒力的最新研究进展。
Clin Microbiol Rev. 2022 Jan 19;35(1):e0000621. doi: 10.1128/CMR.00006-21. Epub 2021 Dec 1.
3
Genomic Investigation Reveals Contaminated Detergent as the Source of an Extended-Spectrum-β-Lactamase-Producing Klebsiella michiganensis Outbreak in a Neonatal Unit.基因组调查揭示，受污染的洗涤剂是新生儿病房产超广谱β-内酰胺酶的密歇根克雷伯菌暴发的源头。
J Clin Microbiol. 2020 Apr 23;58(5). doi: 10.1128/JCM.01980-19.
4
Unusual carbapenem resistant but ceftriaxone and cefepime susceptible isolated from a blood culture: Case report and whole-genome sequencing investigation.从血培养中分离出的对碳青霉烯类耐药但对头孢曲松和头孢吡肟敏感的罕见菌株：病例报告及全基因组测序研究
IDCases. 2017 Nov 23;11:9-11. doi: 10.1016/j.idcr.2017.11.007. eCollection 2018.
5
Characterization of Piperacillin/Tazobactam-Resistant Klebsiella oxytoca Recovered from a Nosocomial Outbreak.从医院感染暴发中分离出的耐哌拉西林/他唑巴坦产酸克雷伯菌的特征分析
PLoS One. 2015 Nov 5;10(11):e0142366. doi: 10.1371/journal.pone.0142366. eCollection 2015.
6
Dissemination of clinical isolates of Klebsiella oxytoca harboring CMY-31, VIM-1, and a New OXY-2-type variant in the community.社区中携带 CMY-31、VIM-1 和新型 OXY-2 型变体的产酸克雷伯菌临床分离株的传播。
Antimicrob Agents Chemother. 2011 Jul;55(7):3164-8. doi: 10.1128/AAC.00102-11. Epub 2011 May 9.
7
Outbreak of OXY-2-Producing Klebsiella oxytoca in a renal transplant unit.肾移植病房产OXY-2的产酸克雷伯菌暴发。
J Clin Microbiol. 2008 Jun;46(6):2099-101. doi: 10.1128/JCM.00194-08. Epub 2008 Apr 16.
8
Six groups of the OXY beta-Lactamase evolved over millions of years in Klebsiella oxytoca.在产酸克雷伯菌中，六组OXYβ-内酰胺酶历经数百万年进化而来。
Antimicrob Agents Chemother. 2005 Aug;49(8):3453-62. doi: 10.1128/AAC.49.8.3453-3462.2005.
9
Chromosome-encoded Ambler class A beta-lactamase of Kluyvera georgiana, a probable progenitor of a subgroup of CTX-M extended-spectrum beta-lactamases.格鲁吉亚克吕沃氏菌的染色体编码的安布勒A类β-内酰胺酶，可能是CTX-M超广谱β-内酰胺酶一个亚组的祖先。
Antimicrob Agents Chemother. 2002 Dec;46(12):4038-40. doi: 10.1128/AAC.46.12.4038-4040.2002.
10
Characterization of a chromosomally encoded extended-spectrum class A beta-lactamase from Kluyvera cryocrescens.来自低温克吕沃尔氏菌的一种染色体编码的超广谱A类β-内酰胺酶的特性分析
Antimicrob Agents Chemother. 2001 Dec;45(12):3595-8. doi: 10.1128/AAC.45.12.3595-3598.2001.
本文引用的文献
1
Chromosomal beta-lactamase genes of Klebsiella oxytoca are divided into two main groups, blaOXY-1 and blaOXY-2.产酸克雷伯菌的染色体β-内酰胺酶基因分为两个主要组，blaOXY-1和blaOXY-2。
Antimicrob Agents Chemother. 1996 Feb;40(2):454-9. doi: 10.1128/AAC.40.2.454.
2
beta-Lactamases in laboratory and clinical resistance.实验室及临床耐药中的β-内酰胺酶
Clin Microbiol Rev. 1995 Oct;8(4):557-84. doi: 10.1128/CMR.8.4.557.
3
Klebsiella oxytoca: resistance to aztreonam by overproduction of the chromosomally encoded beta-lactamase.产酸克雷伯菌：通过过量产生染色体编码的β-内酰胺酶对氨曲南耐药。
FEMS Microbiol Lett. 1994 Feb 1;116(1):31-6. doi: 10.1111/j.1574-6968.1994.tb06671.x.
4
Method for differentiating Klebsiella planticola and Klebsiella terrigena from other Klebsiella species.从其他克雷伯菌属物种中鉴别植生克雷伯菌和土生克雷伯菌的方法。
J Clin Microbiol. 1994 Apr;32(4):1121-2. doi: 10.1128/jcm.32.4.1121-1122.1994.
5
Point mutation in the pribnow box, the molecular basis of beta-lactamase overproduction in Klebsiella oxytoca.肺炎克雷伯菌中β-内酰胺酶过量产生的分子基础——普里布诺框中的点突变
Antimicrob Agents Chemother. 1995 Jun;39(6):1365-8. doi: 10.1128/AAC.39.6.1365.
6
Compilation and analysis of Escherichia coli promoter DNA sequences.大肠杆菌启动子DNA序列的汇编与分析
Nucleic Acids Res. 1983 Apr 25;11(8):2237-55. doi: 10.1093/nar/11.8.2237.
7
Sequence elements determining ampC promoter strength in E. coli.决定大肠杆菌中AmpC启动子强度的序列元件。
EMBO J. 1982;1(7):875-81. doi: 10.1002/j.1460-2075.1982.tb01263.x.
8
The reduction and restoration of galactose transport in osmotically shocked cells of Escherichia coli.大肠杆菌渗透休克细胞中半乳糖转运的降低与恢复
J Biol Chem. 1967 Mar 10;242(5):793-800.
9
Chromosomal beta-lactamase of Klebsiella oxytoca, a new class A enzyme that hydrolyzes broad-spectrum beta-lactam antibiotics.产酸克雷伯菌的染色体β-内酰胺酶，一种可水解广谱β-内酰胺抗生素的新型A类酶。
Antimicrob Agents Chemother. 1989 Jan;33(1):63-70. doi: 10.1128/AAC.33.1.63.
10
Immunological comparison of constitutive beta-lactamases of gram-negative bacteria by neutralization in zymogram gels: properties of anti-TEM-1 and anti-TEM-2 sera.通过酶谱凝胶中的中和作用对革兰氏阴性菌组成型β-内酰胺酶进行免疫比较：抗TEM-1和抗TEM-2血清的特性
Ann Inst Pasteur Microbiol. 1988 Jul-Aug;139(4):435-51.
Zotero 插件