Marklund L, Johansson Moller M, Høyheim B, Davies W, Fredholm M, Juneja R K, Mariani P, Coppieters W, Ellegren H, Andersson L
Department of Animal Breeding and Genetics, Swedish University of Agricultural Sciences, Uppsala, Sweden.
Anim Genet. 1996 Aug;27(4):255-69. doi: 10.1111/j.1365-2052.1996.tb00487.x.
A comprehensive linkage map, including 236 linked markers with a total sex-average map length of about 2300 cM, covering nearly all parts of the pig genome has been established. Linkage groups were assigned to approximately all 18 autosomes, the X chromosome and the X/Y pseudoautosomal region. Several new gene assignments were made including the assignment of linkage group U1 (EAK-HPX) to chromosome 9. The linkage map includes 77 types I loci informative for comparative mapping and 72 in situ mapped markers physically anchoring the linkage groups on chromosomes. A highly significant heterogeneity in recombination rates between sexes was observed with a general tendency towards an excess of female recombination. The average ratio of female to male recombination was estimated at 1.4:1 but this parameter varied between chromosomes as well as between regions within chromosomes. An intriguing finding was that blood group loci were overrepresented at the distal ends of linkage groups.
已构建了一个全面的连锁图谱，包含236个连锁标记，总性别平均图谱长度约为2300厘摩，覆盖了猪基因组的几乎所有部分。连锁群被分配到大约所有18条常染色体、X染色体和X/Y假常染色体区域。进行了几项新的基因定位，包括将连锁群U1（EAK-HPX）定位到9号染色体。该连锁图谱包括77个用于比较作图的I型信息位点和72个通过原位杂交定位的标记，这些标记将连锁群物理定位到染色体上。观察到两性之间的重组率存在高度显著的异质性，总体趋势是雌性重组过多。雌性与雄性重组的平均比率估计为1.4:1，但该参数在不同染色体以及染色体内的不同区域之间有所变化。一个有趣的发现是，血型位点在连锁群的远端过度富集。
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