Chanal C, Sirot D, Romaszko J P, Bret L, Sirot J
Laboratoire de Bactériologie, Faculté de Médecine, Clermont-Ferrand, France.
J Antimicrob Chemother. 1996 Jul;38(1):127-32. doi: 10.1093/jac/38.1.127.
During the first six months of 1990 and 1994 respectively, 3179 and 2721 non-repetitive strains of Enterobacteriaceae were isolated at the teaching hospital of Clermont-Ferrand. Extended-spectrum beta-lactamases were found in 147 isolates, mainly in Klebsiella pneumoniae (n = 73), Enterobacter aerogenes (n = 37) and Proteus mirabilis (n = 15). TEM-3/CTX-1, SHV-4/CAZ-5 and TEM-24/CAZ-6 were the prevalent enzymes. However, the most frequently involved enzyme in 1990 was TEM-3 (48.6%) whereas in 1994 it was SHV-4 (56.0%). Two salient features emerged from this study: the high frequency of TEM-3 production in P. mirabilis and the production of SHV-4 enzyme, heretofore observed solely in K. pneumoniae, in two other species, E. aerogenes and Escherichia coli.
在1990年和1994年的前六个月，克莱蒙费朗教学医院分别分离出3179株和2721株非重复性肠杆菌科菌株。在147株分离菌中发现了超广谱β-内酰胺酶，主要存在于肺炎克雷伯菌（n = 73）、产气肠杆菌（n = 37）和奇异变形杆菌（n = 15）中。TEM-3/CTX-1、SHV-4/CAZ-5和TEM-24/CAZ-6是主要的酶。然而，1990年最常见的酶是TEM-3（48.6%），而1994年是SHV-4（56.0%）。这项研究出现了两个显著特征：奇异变形杆菌中TEM-3产生的高频率，以及SHV-4酶的产生，此前仅在肺炎克雷伯菌中观察到，现在在另外两个物种产气肠杆菌和大肠杆菌中也观察到了。
