Kim J P, Kim W G, Koshino H, Jung J, Yoo I D
Korea Research Institute of Bioscience and Biotechnology, Korea Institute of Science & Technology, Yusong, Taejon, Korea.
Phytochemistry. 1996 Sep;43(2):425-30. doi: 10.1016/0031-9422(96)00279-8.
Three new sesquiterpene ortho-naphthoquinones, davidianones A, B and C, together with four known compounds, mansonones E, F, H and I, were isolated from the root bark of Ulmus davidiana. On the basis of spectral data including pulse field gradient two-dimensional NMR spectroscopy, the structures of new compounds were established as 3-hydroxymethyl-6,9-dimethylnaphtho(1,8-b,c)pyran-7,8-dione, 6-methoxycarbonyl-3,9-dimethylnaphtho(1,8-b,c)pyran-7,8-dione, 6-dimethoxymethyl-3,9-dimethylnaphtho(1.8-b,c)pyran-7,8-d ion e, respectively. Their antioxidative activities were evaluated by a thiobarbituric acid method using rat liver microsomes, with mansonone F showing the greatest activity.
从毛榆根皮中分离出三种新的倍半萜邻萘醌类化合物，即大卫醌A、B和C，以及四种已知化合物，即曼森酮E、F、H和I。基于包括脉冲场梯度二维核磁共振光谱在内的光谱数据，确定新化合物的结构分别为3-羟甲基-6,9-二甲基萘并(1,8-b,c)吡喃-7,8-二酮、6-甲氧基羰基-3,9-二甲基萘并(1,8-b,c)吡喃-7,8-二酮、6-二甲氧基甲基-3,9-二甲基萘并(1.8-b,c)吡喃-7,8-二酮。采用硫代巴比妥酸法，以大鼠肝微粒体为材料评价了它们的抗氧化活性，结果表明曼森酮F的活性最强。
