Lin C C, Lu J M, Yang J J, Chuang S C, Ujiie T
Graduate Institute of Pharmaceutical Sciences, Kaohsiung Medical College, Taiwan.
Am J Chin Med. 1996;24(2):127-37. doi: 10.1142/S0192415X96000177.
The effects of Arctium lappa L. (root) on anti-inflammatory and free radical scavenger activity were investigated. Subcutaneous administration of A. lappa crude extract significantly decreased carrageenan-induced rat paw edema. When simultaneously treated with CCl4, it produced pronounced activities against CCl4-induced acute liver damage. The free radical scavenging activity of its crude extract was also examined by means of an electron spin resonance (ESR) spectrometer. The IC50 of A. lappa extract on superoxide and hydroxyl radical scavenger activity was 2.06 mg/ml and 11.8 mg/ml, respectively. These findings suggest that Arctium lappa possess free radical scavenging activity. The inhibitory effects on carrageenan-induced paw edema and CCl4-induced hepatotoxicity could be due to the scavenging effect of A. lappa.
研究了牛蒡（根）的抗炎和自由基清除活性。皮下注射牛蒡粗提物可显著减轻角叉菜胶诱导的大鼠足肿胀。当与四氯化碳同时处理时，它对四氯化碳诱导的急性肝损伤具有显著活性。还通过电子自旋共振（ESR）光谱仪检测了其粗提物的自由基清除活性。牛蒡提取物对超氧化物和羟基自由基清除活性的IC50分别为2.06 mg/ml和11.8 mg/ml。这些发现表明牛蒡具有自由基清除活性。对角叉菜胶诱导的足肿胀和四氯化碳诱导的肝毒性的抑制作用可能归因于牛蒡的清除作用。
