乙肝表面抗原阴性慢性活动性肝炎中的人类白细胞抗原与细胞介导免疫
HLA and cell-mediated immunity in HBsAg negative chronic active hepatitis.
作者信息
Vogten A J, Shorter R G, Opelz G
出版信息
Gut. 1979 Jun;20(6):523-5. doi: 10.1136/gut.20.6.523.
Abstract
In 20 patients with severe HBsAg negative chronic active hepatitis a significant association has been found between the HLA determinants A1, B8, and Dw3 and cell-mediated immunity directed against human liver specific lipoprotein in vitro. This observation induces further speculation that genetic immunoregulatory action might be involved in the pathogenetic mechanisms of chronic active hepatitis in vivo.
摘要
在20例严重的HBsAg阴性慢性活动性肝炎患者中，已发现HLA决定簇A1、B8和Dw3与体外针对人肝特异性脂蛋白的细胞介导免疫之间存在显著关联。这一观察结果引发了进一步的推测，即基因免疫调节作用可能参与了体内慢性活动性肝炎的发病机制。
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