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从油症多氯联苯中毒评估二噁英风险的方法。

Approach to risk assessment of chlorinated dioxins from Yusho PCB poisoning.

作者信息

Masuda Y

机构信息

Daiichi College of Pharmaceutical Sciences, Minami-ku, Fukuoka, Japan.

出版信息

Chemosphere. 1996 Feb;32(3):583-94. doi: 10.1016/0045-6535(95)00314-2.

DOI:10.1016/0045-6535(95)00314-2
PMID:8907236
Abstract

A Japanese was estimated to ingest 3 and 11 pg/kg/day of TEQ from PCDD/PCDFs and coplanar PCBs respectively through foods. A Japanese baby was calculated to consume 100-530 pg/kg/day level of TEQ through breast milk feeding, more than 60% being attributed to TEQ of coplanar PCBs. These intakes of TEQ were compared to the average (154 ng/kg/day) and minimum (28 ng/kg/day) intakes of Yusho, a PCB posioning occurred in Japan in 1968. There are three or four orders of magnitude difference between the daily TEQ intakes of general population and Yusho patients. However, the TEQ intakes by breast milk-fed babies of general population are at least 53 times less than the minimum intake of Yusho patients.

摘要

据估计,一名日本人通过食物分别摄入3皮克/千克/天和11皮克/千克/天的二噁英/多氯二苯并呋喃和共平面多氯联苯的毒性当量。据计算,一名日本婴儿通过母乳喂养摄入的毒性当量水平为100 - 530皮克/千克/天,其中60%以上归因于共平面多氯联苯的毒性当量。这些毒性当量摄入量与1968年在日本发生的多氯联苯中毒事件——油症患者的平均摄入量(154纳克/千克/天)和最低摄入量(28纳克/千克/天)进行了比较。普通人群的每日毒性当量摄入量与油症患者之间存在三到四个数量级的差异。然而,普通人群中通过母乳喂养的婴儿的毒性当量摄入量至少比油症患者的最低摄入量少53倍。

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