Coque T M, Tomayko J F, Ricke S C, Okhyusen P C, Murray B E
Center for the Study of Emerging and Reemerging Pathogens, University of Texas Medical School, Houston 77030, USA.
Antimicrob Agents Chemother. 1996 Nov;40(11):2605-9. doi: 10.1128/AAC.40.11.2605.
The presence of vancomycin-resistant enterococci (VRE) was looked for in fecal samples from 104 healthy volunteers (3 with hospital exposure), 100 selected hospitalized patients, and various environmental sources (44 commercial chickens, 5 farm-raised chickens, 3 turkeys, and 2 chicken farm lagoon slurries). Five probiotic preparations were also studied. No VRE with vanA or vanB genes were isolated from the healthy volunteers without hospital exposure, environmental sources, or probiotic preparations. VRE with vanB were found in the stools of 16% of the high-risk hospitalized patients and in one volunteer with hospital contact. All VRE examined could be classified into one of two clones by pulsed-field gel electrophoresis. VRE from 11 of the colonized patients were quantified and ranged from 10(3) to 10(6) CFU/g of stool. This study, in contrast to findings in Europe, failed to find evidence of VanA- or VanB-type VRE in the community or environmental sources in Houston, Texas, and suggests that these settings are not a likely source of VRE in hospitals in this geographic area.
在104名健康志愿者（其中3名有医院接触史）的粪便样本、100名选定的住院患者以及各种环境来源（44只商业养殖鸡、5只农场养殖鸡、3只火鸡和2份养鸡场泻湖泥浆）中寻找耐万古霉素肠球菌（VRE）。还对5种益生菌制剂进行了研究。在没有医院接触史的健康志愿者、环境来源或益生菌制剂中未分离出携带vanA或vanB基因的VRE。在16%的高危住院患者粪便以及1名有医院接触史的志愿者粪便中发现了携带vanB的VRE。通过脉冲场凝胶电泳，所有检测的VRE可分为两个克隆之一。对11名定植患者的VRE进行了定量，范围为每克粪便10³至10⁶CFU。与欧洲的研究结果不同，本研究未能在德克萨斯州休斯顿的社区或环境来源中找到VanA或VanB型VRE的证据，这表明在该地理区域的医院中，这些环境不太可能是VRE的来源。
