Thal L A, Chow J W, Mahayni R, Bonilla H, Perri M B, Donabedian S A, Silverman J, Taber S, Zervos M J
Department of Medicine, William Beaumont Hospital, Royal Oak, Michigan 48073, USA.
Antimicrob Agents Chemother. 1995 Sep;39(9):2112-5. doi: 10.1128/AAC.39.9.2112.
Among 97 enterococci cultured from animals, gentamicin MICs were > or = 2,000 micrograms/ml for 9 isolates and between 250 and 1,024 micrograms/ml for 6 isolates. For two isolates tested (gentamicin MICs, 256 and 512 micrograms/ml, respectively), there was no in vitro synergy with penicillin plus gentamicin, resistance was transferable, and there was no hybridization with a probe specific for 6'-aminoglycoside acetyltransferase-2"-aminoglycoside phosphotransferase. The results of the study indicate the presence of a unique gentamicin resistance genotype in enterococci of animal origin.
在从动物身上培养出的97株肠球菌中，9株分离菌的庆大霉素最低抑菌浓度（MIC）≥2000微克/毫升，6株分离菌的庆大霉素MIC在250至1024微克/毫升之间。对于所检测的两株分离菌（庆大霉素MIC分别为256和512微克/毫升），青霉素加庆大霉素不存在体外协同作用，耐药性可转移，且与6'-氨基糖苷乙酰转移酶-2''-氨基糖苷磷酸转移酶特异性探针无杂交现象。研究结果表明动物源肠球菌中存在一种独特的庆大霉素耐药基因型。
