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3-Hydroxypropionaldehyde, an inhibitory metabolite of glycerol fermentation to 1,3-propanediol by enterobacterial species.3-羟基丙醛，一种由肠杆菌属细菌将甘油发酵为1,3-丙二醇过程中的抑制性代谢产物。
Appl Environ Microbiol. 1996 Apr;62(4):1448-51. doi: 10.1128/aem.62.4.1448-1451.1996.
2
3-Hydroxypropionaldehyde guided glycerol feeding strategy in aerobic 1,3-propanediol production by Klebsiella pneumoniae.肺炎克雷伯菌有氧生产1,3-丙二醇中3-羟基丙醛引导的甘油补料策略
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Bacterial conversion of glycerol to beta-hydroxypropionaldehyde.甘油向β-羟基丙醛的细菌转化。
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4
Decrease of 3-hydroxypropionaldehyde accumulation in 1,3-propanediol production by over-expressing dhaT gene in Klebsiella pneumoniae TUAC01.通过在肺炎克雷伯菌TUAC01中过表达dhaT基因降低1,3 - 丙二醇生产中3 - 羟基丙醛的积累
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Sensitivity to pH, product inhibition, and inhibition by NAD+ of 1,3-propanediol dehydrogenase purified from Enterobacter agglomerans CNCM 1210.从成团肠杆菌CNCM 1210中纯化得到的1,3 - 丙二醇脱氢酶对pH的敏感性、产物抑制作用及NAD⁺的抑制作用
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3-hydroxypropionaldehyde: applications and perspectives of biotechnological production.3-羟基丙醛：生物技术生产的应用与前景
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Expression of 1,3-propanediol oxidoreductase and its isoenzyme in Klebsiella pneumoniae for bioconversion of glycerol into 1,3-propanediol.表达 1,3-丙二醇氧化还原酶及其同工酶在肺炎克雷伯氏菌中用于生物转化甘油成 1,3-丙二醇。
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High yield 1,3-propanediol production by rational engineering of the 3-hydroxypropionaldehyde bottleneck in Citrobacter werkmanii.通过对沃氏柠檬酸杆菌中3-羟基丙醛瓶颈进行合理工程改造实现高产1,3-丙二醇。
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Elevated 3-hydroxypropionaldehyde production from glycerol using a Citrobacter freundii mutant.利用弗氏柠檬酸杆菌突变体提高甘油生成3-羟基丙醛的产量。
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Optimizing aerobic conversion of glycerol to 3-hydroxypropionaldehyde.优化甘油向3-羟基丙醛的好氧转化。
Appl Environ Microbiol. 1985 Dec;50(6):1444-50. doi: 10.1128/aem.50.6.1444-1450.1985.

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Gut microbial beta-glucuronidase and glycerol/diol dehydratase activity contribute to dietary heterocyclic amine biotransformation.肠道微生物 β-葡萄糖醛酸酶和甘油/二醇脱水酶活性有助于膳食杂环胺的生物转化。
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High-yield production of 1,3-propanediol from glycerol by metabolically engineered .通过代谢工程从甘油高产生产1,3 - 丙二醇
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Diverse genetic error modes constrain large-scale bio-based production.多样的基因错误模式限制了大规模生物基生产。
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3-Hydroxypropionaldehyde production from crude glycerol by with enhanced glycerol uptake.通过增强甘油摄取从粗甘油生产3-羟基丙醛
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Engineering an aldehyde dehydrogenase toward its substrates, 3-hydroxypropanal and NAD, for enhancing the production of 3-hydroxypropionic acid.工程化醛脱氢酶以适应其底物 3-羟基丙醛和 NAD，以提高 3-羟基丙酸的产量。
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本文引用的文献

1
Optimizing aerobic conversion of glycerol to 3-hydroxypropionaldehyde.优化甘油向3-羟基丙醛的好氧转化。
Appl Environ Microbiol. 1985 Dec;50(6):1444-50. doi: 10.1128/aem.50.6.1444-1450.1985.
2
Chemical characterization of an antimicrobial substance produced by Lactobacillus reuteri.罗伊氏乳杆菌产生的一种抗菌物质的化学特性
Antimicrob Agents Chemother. 1989 May;33(5):674-9. doi: 10.1128/AAC.33.5.674.

3-羟基丙醛，一种由肠杆菌属细菌将甘油发酵为1,3-丙二醇过程中的抑制性代谢产物。

3-Hydroxypropionaldehyde, an inhibitory metabolite of glycerol fermentation to 1,3-propanediol by enterobacterial species.

作者信息

Barbirato F, Grivet J P, Soucaille P, Bories A

机构信息

Laboratoire de Biotechnologie de l'Environnement, Institut National de la Recherche Agronomique, Narbonne, France.

出版信息

Appl Environ Microbiol. 1996 Apr;62(4):1448-51. doi: 10.1128/aem.62.4.1448-1451.1996.

DOI:10.1128/aem.62.4.1448-1451.1996
PMID:8919810
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC167915/
Abstract

Glycerol fermentation by Enterobacter agglomerans revealed that both growth and 1,3-propanediol production ceased after consumption of about 430 mM glycerol, irrespective of the initial glycerol content. This phenomenon was assigned to the production of 3-hydroxypropionaldehyde, which was identified by proton nuclear magnetic resonance and which showed a bacteriostatic effect. The accumulation during glycerol fermentation was also observed with two other enterobacterial species, i.e., Klebsiella pneumoniae and Citrobacter freundii.

摘要

聚团肠杆菌进行甘油发酵的结果表明，无论初始甘油含量如何，在消耗约430 mM甘油后，生长和1,3 - 丙二醇的产生均停止。这种现象归因于3 - 羟基丙醛的产生，通过质子核磁共振鉴定该物质具有抑菌作用。在另外两种肠杆菌，即肺炎克雷伯菌和弗氏柠檬酸杆菌的甘油发酵过程中也观察到了这种积累现象。