Wald N J, Boreham J, Hayward J L, Bulbrook R D
Br J Cancer. 1984 Mar;49(3):321-4. doi: 10.1038/bjc.1984.50.
In a prospective study of 5,004 women in Guernsey, plasma samples were collected and stored. Retinol, beta-carotene and vitamin E levels were later measured in the samples from 39 women who subsequently developed breast cancer and from 78 controls who did not develop cancer. Plasma retinol levels were not related to the risk of breast cancer, mean levels among cases and controls being 485 micrograms l-1 and 479 micrograms l-1 respectively. Plasma vitamin E levels showed a clear association, low levels being associated with a significantly higher risk of cancer. The mean vitamin E levels among cases and controls were 4.7 mg l-1 and 6.0 mg l-1 respectively (P less than 0.025), and the risk of breast cancer in women with vitamin E levels in the lowest quintile was about 5-times higher than the risk for women with levels in the highest quintile (P less than 0.01). beta-carotene levels showed a tendency to be lower in women who developed cancer than in controls (36 micrograms l-1 among cases compared with 50 micrograms l-1 among controls) but the difference was not statistically significant.
在一项对根西岛5004名女性的前瞻性研究中，采集并储存了她们的血浆样本。随后对39名后来患乳腺癌的女性和78名未患癌症的对照者的样本进行了视黄醇、β-胡萝卜素和维生素E水平的测量。血浆视黄醇水平与患乳腺癌的风险无关，病例组和对照组的平均水平分别为485微克/升和479微克/升。血浆维生素E水平呈现出明显的关联，低水平与显著更高的癌症风险相关。病例组和对照组的平均维生素E水平分别为4.7毫克/升和6.0毫克/升（P<0.025），维生素E水平处于最低五分位数的女性患乳腺癌的风险约为处于最高五分位数女性的5倍（P<0.01）。β-胡萝卜素水平在患癌女性中显示出比对照组更低的趋势（病例组为36微克/升，对照组为50微克/升），但差异无统计学意义。
