Yamazaki S, Inoue Y, Yoshikawa K
Department of Ophthalmology, Tokyo Medical and Dental University School of Medicine, Japan.
Br J Ophthalmol. 1996 Sep;80(9):812-7. doi: 10.1136/bjo.80.9.812.
Detailed fluorescein angiographic findings in the disc circumference may be useful for evaluating the possible relation of the circumference to glaucomatous nerve damage.
Fluorescein angiograms of 25 eyes of 25 subjects with primary open angle glaucoma were observed after they had undertaken Octopus perimetry. Based on the retinotopic projection, disc sectors and corresponding visual field regions were set.
Twenty three eyes (92%) showed a zone of no fluorescence around the disc (non-fluorescent zone). Of these, the zone width of the 20 eyes that had visible ciliary vessels within the zone was wider than that of the other three eyes, and showed fluorescein diffusion from the outer boundary of the zone towards the disc. The diffusion reached the disc if the zone was narrow. In those 20 eyes, a standardised difference in the zone width of inferior temporal sector minus superior temporal sector correlated with the difference in mean loss of corresponding visual field regions (r = 0.48, p = 0.0312).
The visible ciliary vessels suggest the absence of the choriocapillaris in the non-fluorescent zone, the width of which correlated with the visual field defect and may affect the amount of the fluorescein diffusion to the disc. This suggests that the diffusion might be related to optic nerve damage in glaucoma.
视盘周边详细的荧光素血管造影结果可能有助于评估周边与青光眼性神经损伤之间的可能关系。
对25例原发性开角型青光眼患者的25只眼进行荧光素血管造影，这些患者均已进行了Octopus视野检查。根据视网膜定位投影，设定视盘扇形区和相应的视野区域。
23只眼（92%）在视盘周围显示无荧光区（非荧光区）。其中，该区域内可见睫状血管的20只眼的区域宽度比其他三只眼宽，且显示荧光素从该区域的外边界向视盘扩散。如果该区域狭窄，扩散会到达视盘。在这20只眼中，颞下扇形区与颞上扇形区区域宽度的标准化差值与相应视野区域平均缺损的差值相关（r = 0.48，p = 0.0312）。
可见睫状血管提示非荧光区内无脉络膜毛细血管，其宽度与视野缺损相关，可能影响荧光素向视盘的扩散量。这表明这种扩散可能与青光眼的视神经损伤有关。
