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麻风分枝杆菌新蛋白的分子定义与鉴定

Molecular definition and identification of new proteins of Mycobacterium leprae.

作者信息

Pessolani M C, Brennan P J

机构信息

Department of Microbiology, Colorado State University, Fort Collins 80523, USA.

出版信息

Infect Immun. 1996 Dec;64(12):5425-7. doi: 10.1128/iai.64.12.5425-5427.1996.

DOI:10.1128/iai.64.12.5425-5427.1996
PMID:8945601
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC174543/
Abstract

This report describes N-terminal group analysis of six new proteins isolated from in vivo-grown Mycobacterium leprae, three of which correspond to products of the cysA, ahpC, and rpIL genes, which were recently defined through the M. leprae genome project and which encode a putative sulfate sulfurtransferase, an antioxidant enzyme, and the L7/L12 ribosomal protein, respectively.

摘要

本报告描述了从体内生长的麻风分枝杆菌中分离出的六种新蛋白质的N端基团分析，其中三种分别对应于cysA、ahpC和rpIL基因的产物，这些基因最近通过麻风分枝杆菌基因组计划得以确定，分别编码一种假定的硫酸硫转移酶、一种抗氧化酶和L7/L12核糖体蛋白。

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本文引用的文献

1
The role of nitrogen oxides as effector molecules of parasite killing.氮氧化物作为寄生虫杀伤效应分子的作用。
Parasitol Today. 1990 Sep;6(9):303-5. doi: 10.1016/0169-4758(90)90261-2.
2
ahpC, a gene involved in isoniazid resistance of the Mycobacterium tuberculosis complex.ahpC，一种参与结核分枝杆菌复合群异烟肼耐药性的基因。
Mol Microbiol. 1996 Mar;19(5):1025-34. doi: 10.1046/j.1365-2958.1996.449980.x.
3
Immunological and functional characterization of Mycobacterium leprae protein antigens: an overview.麻风分枝杆菌蛋白抗原的免疫学及功能特性概述
Mol Microbiol. 1995 Dec;18(5):791-800. doi: 10.1111/j.1365-2958.1995.18050791.x.
4
Mycobacterium tuberculosis is a natural mutant with an inactivated oxidative-stress regulatory gene: implications for sensitivity to isoniazid.结核分枝杆菌是一种具有失活氧化应激调节基因的天然突变体：对异烟肼敏感性的影响。
Mol Microbiol. 1995 Sep;17(5):889-900. doi: 10.1111/j.1365-2958.1995.mmi_17050889.x.
5
Nucleotide sequence of the first cosmid from the Mycobacterium leprae genome project: structure and function of the Rif-Str regions.来自麻风分枝杆菌基因组计划的首个黏粒的核苷酸序列：利福平 - 链霉素抗性区域的结构与功能
Mol Microbiol. 1993 Jan;7(2):207-14. doi: 10.1111/j.1365-2958.1993.tb01112.x.
6
Use of an ordered cosmid library to deduce the genomic organization of Mycobacterium leprae.利用有序黏粒文库推导麻风分枝杆菌的基因组结构。
Mol Microbiol. 1993 Jan;7(2):197-206. doi: 10.1111/j.1365-2958.1993.tb01111.x.
7
Purification, characterization, gene sequence, and significance of a bacterioferritin from Mycobacterium leprae.麻风分枝杆菌细菌铁蛋白的纯化、特性、基因序列及意义
J Exp Med. 1994 Jul 1;180(1):319-27. doi: 10.1084/jem.180.1.319.
8
Regulation of bacterial gene expression in response to oxidative stress.细菌基因表达对氧化应激的响应调控。
Methods Enzymol. 1994;236:196-207. doi: 10.1016/0076-6879(94)36017-0.
9
MycDB: an integrated mycobacterial database.MycDB：一个综合性分枝杆菌数据库。
Mol Microbiol. 1994 May;12(4):517-34. doi: 10.1111/j.1365-2958.1994.tb01039.x.
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Chemical definition, cloning, and expression of the major protein of the leprosy bacillus.麻风杆菌主要蛋白质的化学定义、克隆及表达
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