Socié G, Medhi Sohrabi K, Carosella E D, Cosset J M, Hervatin F, de Cremoux P, Dutrillaux B, Sheibani K M, Rabian C, Gourmelon P, Parmentier C, Gluckman E
Service de recherches en hémato-immunologie, Hôpital Saint-Louis, Paris, France.
C R Acad Sci III. 1996 Aug;319(8):711-6.
Over the past few years there have been 2 radiation-related accidents involving a large number of individuals: the April 1986 accident in Chernobyl nuclear power station in the Ukraine and the September 1987 accident in Goiania, Brazil. These 2 radiation-related accidents highlight the major question raised by radiation-induced injury to the haematopoietic system, that is: does a given patient suffer from a reversible or an irreversible haematopoietic stem cell damage? Although about 350 radiation accidents involving several thousand people are known from the literature, in-depth haematopoiesis analyses of individuals after a radiation-related accident have rarely been reported. In this paper we present the case of a young man with radiation-induced aplasia and compare some biological data to those of 16 normal individuals and of 17 patients with acquired aplastic anaemia. Our patient was clinically and biologically (as assessed by long-term bone marrow culture) indistinguishable from patients with idiopathic acquired aplastic anaemia. Furthermore, therapeutic attitudes in this patient are discussed. In-depth study of such radiation-induced aplastic anaemia cases can shed some light in the understanding of this disease and may help in therapeutic decisions.
在过去几年中，发生了两起涉及大量人员的与辐射相关的事故：1986年4月发生在乌克兰切尔诺贝利核电站的事故，以及1987年9月发生在巴西戈亚尼亚的事故。这两起与辐射相关的事故凸显了辐射对造血系统造成损伤所引发的主要问题，即：特定患者是否遭受了可逆或不可逆的造血干细胞损伤？尽管从文献中可知约有350起涉及数千人的辐射事故，但很少有关于辐射相关事故后个体造血功能的深入分析报道。在本文中，我们介绍了一名患有辐射诱导再生障碍性贫血的年轻男子的病例，并将一些生物学数据与16名正常个体以及17名获得性再生障碍性贫血患者的数据进行了比较。我们的患者在临床和生物学方面（通过长期骨髓培养评估）与特发性获得性再生障碍性贫血患者并无差异。此外，还讨论了该患者的治疗态度。对这类辐射诱导再生障碍性贫血病例的深入研究可以为理解这种疾病提供一些线索，并可能有助于治疗决策。
