Bender B G
National Jewish Center for Immunology and Respiratory Medicine, Denver, Colorado, USA.
Ann Allergy Asthma Immunol. 1996 Dec;77(6):438-45; quiz 446-7. doi: 10.1016/S1081-1206(10)63347-9.
This review will provide the reader a current appraisal of attempts to measure quality of life (QoL) in pediatric asthma and guidelines toward making a discriminating selection from available QoL questionnaires.
A MEDLINE literature search was performed using the index terms quality of life and asthma. Reference lists from articles identified through this search were also perused. References that did not include the term "quality of life" but clearly addressed this topic were included.
Nine questionnaires employed in studies evaluating life quality associated with pediatric asthma were identified. Five of the questionnaires are parent-completed and four are child-completed. The instruments vary considerably in length and content areas, and most have been used in a single study.
The science of measuring QoL change associated with pediatric asthma is in its infancy and the decision to use any single QoL instrument should be made cautiously. Investigators seeking to employ a QoL questionnaire in pediatric asthma clinical trials must consider several problems specific to evaluation with children, including age effects, reading ability, impact of adult assistance upon responses, and the inclusion of mother- versus father-completed questionnaires. The selected QoL questionnaire should address specific hypotheses and be piloted by the investigator before inclusion in a planned investigation.
本综述将向读者提供对测量儿童哮喘患者生活质量（QoL）的尝试的当前评估，以及从现有的生活质量问卷中进行有鉴别力选择的指南。
使用索引词“生活质量”和“哮喘”进行了MEDLINE文献检索。还查阅了通过该检索确定的文章的参考文献列表。纳入了未包含“生活质量”一词但明确涉及该主题的参考文献。
确定了九份用于评估与儿童哮喘相关的生活质量的问卷。其中五份问卷由家长填写，四份由儿童填写。这些工具在长度和内容领域差异很大，并且大多数仅在一项研究中使用过。
测量与儿童哮喘相关的生活质量变化的科学尚处于起步阶段，使用任何单一的生活质量工具都应谨慎决定。寻求在儿童哮喘临床试验中使用生活质量问卷的研究人员必须考虑一些与儿童评估相关的特定问题，包括年龄影响、阅读能力、成人协助对回答的影响，以及纳入由母亲还是父亲填写的问卷。所选的生活质量问卷应针对特定假设，并在纳入计划调查之前由研究人员进行预试验。
