高同型半胱氨酸血症、幽门螺杆菌与冠心病
Hyperhomocysteinaemia, Helicobacter pylori, and coronary heart disease.
作者信息
Sung J J, Sanderson J E
机构信息
Department of Medicine, Chinese University of Hong Kong, Shatin.
出版信息
Heart. 1996 Oct;76(4):305-7. doi: 10.1136/hrt.76.4.305.
Abstract
Hyperhomocysteinaemia and Helicobacter pylori infection have recently been implicated in the pathogenesis of coronary artery disease. These two risk factors, though they seem unrelated, could be linked by a deficiency of vitamins and folate caused by chronic gastritis in H pylori infection. This nutritional defect could lead to failure of methylation by 5-methyl-tetrahydrofolic acid and thus exacerbate the accumulation of homocysteine in susceptible patients. Homocysteine is toxic to endothelial cells and results in coronary artery disease.
摘要
高同型半胱氨酸血症和幽门螺杆菌感染最近被认为与冠状动脉疾病的发病机制有关。这两种危险因素虽然看似无关，但可能因幽门螺杆菌感染引起的慢性胃炎导致维生素和叶酸缺乏而联系在一起。这种营养缺陷可能导致5-甲基四氢叶酸甲基化失败，从而加剧易感患者体内同型半胱氨酸的积累。同型半胱氨酸对内皮细胞有毒性，会导致冠状动脉疾病。
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