Combes P, Fauvage B, Colonna M, Passagia J G, Chirossel J P, Jacquot C
Département d' Anesthésie Réanimation 1, CHU de Grenoble, France.
Intensive Care Med. 1996 Dec;22(12):1391-5. doi: 10.1007/BF01709556.
To identify the predictors determined early after admission and associated with unfavorable outcome or early (within 48 h) death after severe head injury.
Prospective cohort study.
A neurosurgical intensive care unit in a university hospital.
198 consecutive comatose patients hospitalized from 1989 to 1992.
Logistic regression showed that a combination of age, best motor response score from the Glasgow Coma Scale, and hypoxia provided a good prediction model of unfavorable outcome (sensitivity = 0.93). The length of participation of survivors was 6 to 61 months (median 27.1). The Cox model demonstrated age, motor score less than 3, mydriasis, and hypoxia as poor prognosis factors.
Clinicians can determine the odds of a good outcome from the combination of three easily measurable factors using a simple diagram constructed from logistic regression. Survival analysis showed that motor score adjusted values greater than 3 had the same prognosis.
确定入院后早期确定的、与重型颅脑损伤后不良结局或早期（48小时内）死亡相关的预测因素。
前瞻性队列研究。
一家大学医院的神经外科重症监护病房。
1989年至1992年连续收治的198例昏迷患者。
逻辑回归显示，年龄、格拉斯哥昏迷量表最佳运动反应评分和低氧血症相结合可提供良好的不良结局预测模型（敏感性=0.93）。幸存者的参与时长为6至61个月（中位数27.1）。Cox模型显示年龄、运动评分低于3分、瞳孔散大和低氧血症为预后不良因素。
临床医生可以使用由逻辑回归构建的简单图表，通过三个易于测量的因素的组合来确定良好结局的几率。生存分析表明，运动评分校正值大于3具有相同的预后。
