Seppäläinen A M, Raitta C, Huuskonen M S
Electroencephalogr Clin Neurophysiol. 1979 Oct;47(4):492-8. doi: 10.1016/0013-4694(79)90165-2.
Visual evoked potentials (VEPs) and averaged extraocular electroretinograms (ERGs) were recorded from 15 workers occupationally exposed to n-hexane for 5-21 years and from 10 healthy control persons. The amplitude of the VEP components was clearly smaller among the exposed subjects with the exception of N0, which tended to be larger. In addition, the latencies of P1 and N1 were longer among the exposed workers, while that of P2 was slightly shorter. The peak-to-peak amplitude of the ERGs was also diministed among the exposed subjects. The changes were interpreted to indicate cerebral dysfunction, probably conduction block in intracerebral axons. n-Hexane is an aliphatic hydrocarbon found in gasoline and used in various industrial applications. It has been shown to cause axonal neuropathy of the dying-back type in both experimental animals and humans. According to the present findings the central nervous system is alos susceptible to the toxic effects of n-hexane.
对15名职业性接触正己烷5至21年的工人以及10名健康对照者记录了视觉诱发电位（VEP）和平均眼外视网膜电图（ERG）。除N0成分的振幅在接触者中倾向于增大外，VEP各成分的振幅在接触者中明显较小。此外，接触工人中P1和N1的潜伏期较长，而P2的潜伏期稍短。ERG的峰峰值振幅在接触者中也减小。这些变化被解释为表明存在脑功能障碍，可能是脑内轴突传导阻滞。正己烷是一种存在于汽油中并用于各种工业用途的脂肪烃。已表明它在实验动物和人类中均可引起轴索性回返性神经病。根据目前的研究结果，中枢神经系统也易受正己烷毒性作用的影响。
