Beyer W E, Palache A M, Sprenger M J, Hendriksen E, Tukker J J, Darioli R, van der Water G L, Masurel N, Osterhaus A D
WHO National Influenza Centre, Institute of Virology, Erasmus University Rotterdam, The Netherlands.
Vaccine. 1996 Oct;14(14):1331-9. doi: 10.1016/s0264-410x(96)00058-8.
Three cohort studies in adults were performed during the period from 1986 to 1989. Eight hundred and eighty-four subjects were, one or more times, immunized with influenza vaccines, and pre- and post-vaccination antibody titres were determined by hemagglutination inhibition tests. One thousand and one hundred and nineteen vaccination events in 681 subjects could be analysed by a comparison, per trial and per influenza (sub)type, between groups with and without influenza vaccination in previous years. Effect size, odds ratio and protection rate difference, were used as effect measures. Subjects with previous vaccination showed higher pre-vaccination antibody than those without. The average change of the post-vaccination proportion of subjects with high antibody titre value to previous vaccination, was +9.4% (95% CI: +5.3 to 13.6%) for A-H3N2 vaccine components, -2.1% (-8.1 to 3.9%, not significant) for A-H1N1 and -10.6% (-16.5% to -4.8%) for B. In a linear regression model, pre-vaccination titres and the status of previous vaccination were identified as factors significantly influencing post-vaccination titres. These findings are discussed in the context of a short review of the literature. It is concluded that the status of previous vaccination should always be addressed as an independent factor in serological vaccination studies.
在1986年至1989年期间开展了三项针对成年人的队列研究。884名受试者接受了一次或多次流感疫苗免疫接种，并通过血凝抑制试验测定了接种疫苗前后的抗体滴度。通过对在前些年接种过流感疫苗组和未接种组数据进行对比分析681名受试者的1119次疫苗接种情况，每次试验和每种流感（亚）型均进行了分析。效应量、比值比和保护率差异用作效应指标。既往接种过疫苗的受试者接种前抗体水平高于未接种者。接种A-H3N2疫苗成分后，抗体滴度高的受试者比例平均变化为+9.4%（95%置信区间：+5.3%至13.6%），接种A-H1N1疫苗后为-2.1%（-8.1%至3.9%，无显著性差异），接种B型疫苗后为-10.6%（-16.5%至-4.8%）。在一个线性回归模型中，接种前滴度和既往接种状态被确定为显著影响接种后滴度的因素。这些发现结合文献简短综述进行了讨论。得出的结论是，在血清学疫苗接种研究中，既往接种状态应始终作为一个独立因素加以考虑。
