丝状噬菌体表面不同肽段的同时展示。
Simultaneous display of different peptides on the surface of filamentous bacteriophage.
作者信息
Malik P, Perham R N
机构信息
Cambridge Centre for Molecular Recognition, Department of Biochemistry, University of Cambridge, UK.
出版信息
Nucleic Acids Res. 1997 Feb 15;25(4):915-6. doi: 10.1093/nar/25.4.915.
Abstract
We have developed a new system for producing hybrid virions of filamentous bacteriophage fd simultaneously displaying two different peptides by infecting cells harbouring a plasmid containing a modified gene VIII with an engineered bacteriophage carrying a second and different copy of a modified gene VIII. The simultaneous display of different peptides has many potential applications in exploring the immune response and studying protein-protein interaction.
摘要
我们开发了一种新系统，通过用携带修饰基因VIII的第二个不同拷贝的工程噬菌体感染含有修饰基因VIII质粒的细胞，来生产同时展示两种不同肽段的丝状噬菌体fd杂交病毒粒子。不同肽段的同时展示在探索免疫反应和研究蛋白质-蛋白质相互作用方面有许多潜在应用。
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本文引用的文献
1
Role of capsid structure and membrane protein processing in determining the size and copy number of peptides displayed on the major coat protein of filamentous bacteriophage.衣壳结构和膜蛋白加工在决定丝状噬菌体主要衣壳蛋白上展示的肽段大小和拷贝数方面的作用。
J Mol Biol. 1996 Jul 5;260(1):9-21. doi: 10.1006/jmbi.1996.0378.
2
New vectors for peptide display on the surface of filamentous bacteriophage.用于在丝状噬菌体表面展示肽的新型载体。
Gene. 1996 May 24;171(1):49-51. doi: 10.1016/0378-1119(96)00070-4.
3
Modifying filamentous phage capsid: limits in the size of the major capsid protein.修饰丝状噬菌体衣壳：主要衣壳蛋白大小的限制
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Engineering a peptide epitope display system on filamentous bacteriophage.
FEMS Microbiol Rev. 1995 Aug;17(1-2):25-31. doi: 10.1111/j.1574-6976.1995.tb00184.x.
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Searching for peptide ligands with an epitope library.利用表位文库寻找肽配体。
Science. 1990 Jul 27;249(4967):386-90. doi: 10.1126/science.1696028.
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