丝状噬菌体表面不同肽段的同时展示。
Simultaneous display of different peptides on the surface of filamentous bacteriophage.
作者信息
Malik P, Perham R N
机构信息
Cambridge Centre for Molecular Recognition, Department of Biochemistry, University of Cambridge, UK.
出版信息
Nucleic Acids Res. 1997 Feb 15;25(4):915-6. doi: 10.1093/nar/25.4.915.
Abstract
We have developed a new system for producing hybrid virions of filamentous bacteriophage fd simultaneously displaying two different peptides by infecting cells harbouring a plasmid containing a modified gene VIII with an engineered bacteriophage carrying a second and different copy of a modified gene VIII. The simultaneous display of different peptides has many potential applications in exploring the immune response and studying protein-protein interaction.
摘要
我们开发了一种新系统，通过用携带修饰基因VIII的第二个不同拷贝的工程噬菌体感染含有修饰基因VIII质粒的细胞，来生产同时展示两种不同肽段的丝状噬菌体fd杂交病毒粒子。不同肽段的同时展示在探索免疫反应和研究蛋白质-蛋白质相互作用方面有许多潜在应用。
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