Desai S S, Ghaisas S D, Jakhi S D, Bhide S V
Swami Prakashananda Ayurveda Research Centre, Juhu, Bombay, India.
Cancer Lett. 1996 Dec 3;109(1-2):9-14. doi: 10.1016/s0304-3835(96)04390-x.
One hundred patients suffering from oral submucous fibrosis (OSF), oral leukoplakia (OL) and oral lichen planus (OLP) were studied for the cytogenetic damage in oral mucosal cells and in circulating lymphocytes along with their habit patterns. It was observed that OSF was largely associated with betel nut containing masticants while OL was associated with chewing or smoking habit. It was further observed that their exfoliated oral mucosal cells had significantly higher numbers of micronucleated (Mn) cells as compared to these of healthy normal subjects without any chewing or smoking habit. Similar cytogenetic damage in the form of increased sister chromatid exchanges (SCE) was observed in circulating lymphocytes indicating that the carcinogenic agents produce damage not only in target tissue but also in other host cells such as circulating lymphocytes.
对100名患有口腔黏膜下纤维化（OSF）、口腔白斑（OL）和口腔扁平苔藓（OLP）的患者进行了研究，观察其口腔黏膜细胞和循环淋巴细胞的细胞遗传学损伤以及他们的习惯模式。观察到OSF主要与含槟榔的咀嚼物有关，而OL与咀嚼或吸烟习惯有关。进一步观察发现，与没有任何咀嚼或吸烟习惯的健康正常受试者相比，他们脱落的口腔黏膜细胞中微核（Mn）细胞数量明显更多。在循环淋巴细胞中也观察到了类似的以姐妹染色单体交换（SCE）增加形式的细胞遗传学损伤，这表明致癌剂不仅会在靶组织中产生损伤，还会在其他宿主细胞如循环淋巴细胞中产生损伤。
