Chia S E, Foo S C, Khoo N Y, Jeyaratnam J
Department of Community, Occupational, and Family Medicine, National University of Singapore, Singapore.
Am J Ind Med. 1997 Feb;31(2):148-52. doi: 10.1002/(sici)1097-0274(199702)31:2<148::aid-ajim3>3.0.co;2-w.
The objectives of this study were to determine the exposure levels among workers who handle 2-ethoxyethylacetate (EGEEA) in the liquid crystal display (LCD) manufacturing industry and to study the menstrual patterns among the exposed workers compared to a referent group of workers. A total of 52 female exposed workers and 55 referents was studied. Detailed menstrual histories were obtained by personal interview using a structured questionnaire. All the exposed had individual 8-hour personal monitoring for EGEEA in the environment and start-of-shift and end-of-shift urine analysis for EGEEA concentration. The geometric mean end-of-shift urine EGEEA concentration was 0.16 mg/g creatinine. End-of-shift urine EGEEA was well correlated with the air concentration; r = 0.81 [p < 0.0001]. No significant differences were observed between the exposed and referent groups for duration of each menstrual cycle (period), duration (days) of the menses, and the amount of flow, even after adjusting for possible confounders viz. age, years of education, use of oral contraceptive pills, age at menarche, gravidity, and race. The workers in the LCD manufacturing industry were exposed to a mean TWA of 0.51 ppm of EGEEA. At this concentration, the findings did not reveal any significant difference between the menstrual patterns of the exposed and referent subjects.
本研究的目的是确定液晶显示器（LCD）制造业中接触2-乙氧基乙酸乙酯（EGEEA）的工人的暴露水平，并将暴露工人的月经模式与对照组工人进行比较。共研究了52名女性暴露工人和55名对照者。通过使用结构化问卷进行个人访谈获得详细的月经史。所有暴露者均对工作环境中的EGEEA进行了8小时个人监测，并对轮班开始和结束时的尿液进行了EGEEA浓度分析。轮班结束时尿液中EGEEA的几何平均浓度为0.16mg/g肌酐。轮班结束时尿液中的EGEEA与空气浓度密切相关；r = 0.81 [p < 0.0001]。即使在对可能的混杂因素（即年龄、受教育年限、口服避孕药的使用、初潮年龄、妊娠次数和种族）进行调整后，暴露组和对照组在每个月经周期的持续时间（经期）、月经持续时间（天数）和月经量方面也未观察到显著差异。LCD制造业的工人平均接触EGEEA的时间加权平均浓度为0.51ppm。在此浓度下，研究结果未显示暴露组和对照组的月经模式之间存在任何显著差异。
