Burgess N, O'Keefe J
Department of Anatomy, University College London, England.
Hippocampus. 1996;6(6):749-62. doi: 10.1002/(SICI)1098-1063(1996)6:6<749::AID-HIPO16>3.0.CO;2-0.
Our model of the spatial and temporal aspects of place cell firing and their role in rat navigation is reviewed. The model provides a candidate mechanism, at the level of individual cells, by which place cell information concerning self-localization could be used to guide navigation to previously visited reward sites. The model embodies specific predictions regarding the formation of place fields, the phase coding of place cell firing with respect to the hippocampal theta rhythm, and the formation of neuronal population vectors downstream from the place cells that code for the directions of goals during navigation. Recent experiments regarding the spatial distribution of place cell firing have confirmed our initial modeling hypothesis, that place fields are formed from Gaussian tuning curve inputs coding for the distances from environmental features, and enabled us to further specify the functional form of these inputs. Other recent experiments regarding the temporal distribution of place cell firing in two-dimensional environments have confirmed our predictions based on the temporal aspects of place cell firing on linear tracks. Directions for further experiments and refinements to the model are outlined for the future.
我们回顾了位置细胞放电的时空方面模型及其在大鼠导航中的作用。该模型在单个细胞层面提供了一种候选机制，通过该机制，有关自我定位的位置细胞信息可用于引导导航至先前访问过的奖励地点。该模型体现了关于位置野形成、位置细胞放电相对于海马θ节律的相位编码以及位置细胞下游编码导航过程中目标方向的神经元群体向量形成的具体预测。最近关于位置细胞放电空间分布的实验证实了我们最初的建模假设，即位置野由编码与环境特征距离的高斯调谐曲线输入形成，并使我们能够进一步明确这些输入的功能形式。最近关于二维环境中位置细胞放电时间分布的其他实验证实了我们基于线性轨道上位置细胞放电时间方面的预测。概述了未来进一步实验和模型改进的方向。
