Terada T, Kitamura Y, Ohta T, Nakanuma Y
Second Department of Pathology, Tottori University Faculty of Medicine, Japan.
Virchows Arch. 1997 Jan;430(1):37-40. doi: 10.1007/BF01008014.
We investigated the distribution of endocrine cells in hepatobiliary cystadenoma (n = 5, two associated with mesenchymal stroma) and cystadenocarcinoma (n = 3) immunohistochemically. In normal livers (n = 20) and livers affected by hepatolithiasis (n = 15) used as controls, endocrine cells revealed by chromogranin immunostaining were located exclusively in normal or proliferating intrahepatic peribiliary glands. In the eight cases of hepatobiliary cystadenoma and cystadenocarcinoma, endocrine cells were present in four cases (50%) (1 cystadenoma, 1 cystadenoma with mesenchymal stroma, and 2 cystadenocarcinomas). Endocrine cells tended to be located beneath and among the columnar epithelial cells. Intrahepatic peribiliary glands were located in the vicinity of cystadenoma or cystadenocarcinoma in six (75%) of the eight cases, and they frequently showed cystic dilatation and contained endocrine cells. Intrahepatic peribiliary glands were located in the vicinity of the endocrine cells in all cystadenomas and cystadenocarcinomas that were positive for endocrine cells. These data show that about 50% of hepatobiliary cystadenomas and cystadenocarcinomas contain endocrine cells and suggest that hepatobiliary cystadenoma and cystadenocarcinoma may originate from intrahepatic peribiliary glands.
我们采用免疫组织化学方法研究了肝胆管囊腺瘤（n = 5，其中两例伴有间充质基质）和囊腺癌（n = 3）中内分泌细胞的分布情况。以正常肝脏（n = 20）和肝内胆管结石病肝脏（n = 15）作为对照，嗜铬粒蛋白免疫染色显示的内分泌细胞仅位于正常或增生的肝内胆管周围腺体中。在8例肝胆管囊腺瘤和囊腺癌中，4例（50%）存在内分泌细胞（1例囊腺瘤、1例伴有间充质基质的囊腺瘤和2例囊腺癌）。内分泌细胞倾向于位于柱状上皮细胞下方及之间。8例中的6例（75%），肝内胆管周围腺体位于囊腺瘤或囊腺癌附近，且常呈囊性扩张并含有内分泌细胞。在所有内分泌细胞呈阳性的囊腺瘤和囊腺癌中，肝内胆管周围腺体均位于内分泌细胞附近。这些数据表明，约50%的肝胆管囊腺瘤和囊腺癌含有内分泌细胞，并提示肝胆管囊腺瘤和囊腺癌可能起源于肝内胆管周围腺体。
