肺炎克雷伯菌喹诺酮耐药临床分离株中DNA促旋酶的GyrA亚基和拓扑异构酶IV的ParC亚基的改变。
Alterations in the GyrA subunit of DNA gyrase and the ParC subunit of topoisomerase IV in quinolone-resistant clinical isolates of Klebsiella pneumoniae.
作者信息
Deguchi T, Fukuoka A, Yasuda M, Nakano M, Ozeki S, Kanematsu E, Nishino Y, Ishihara S, Ban Y, Kawada Y
机构信息
Department of Urology, Gifu University School of Medicine, Japan.
出版信息
Antimicrob Agents Chemother. 1997 Mar;41(3):699-701. doi: 10.1128/AAC.41.3.699.
Abstract
We determined a partial sequence of the Klebsiella pneumoniae parC gene, including the region analogous to the quinolone resistance-determining region of the Escherichia coli gyrA gene, and examined 26 clinical strains of K. pneumoniae for an association of alterations in GyrA and ParC with susceptibilities to quinolones. The study suggests that in K. pneumoniae DNA gyrase is a primary target of quinolones and that ParC alterations play a complementary role in the development of higher-level fluoroquinolone resistance.
摘要
我们测定了肺炎克雷伯菌parC基因的部分序列，包括与大肠杆菌gyrA基因喹诺酮耐药决定区类似的区域，并检测了26株临床分离的肺炎克雷伯菌，以研究GyrA和ParC的改变与喹诺酮敏感性之间的关系。该研究表明，在肺炎克雷伯菌中，DNA回旋酶是喹诺酮的主要作用靶点，而ParC的改变在高水平氟喹诺酮耐药的产生中起互补作用。
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本文引用的文献
1
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Antimicrob Agents Chemother. 1996 Mar;40(3):710-14. doi: 10.1128/AAC.40.3.710.
2
Quinolone-resistant Neisseria gonorrhoeae: correlation of alterations in the GyrA subunit of DNA gyrase and the ParC subunit of topoisomerase IV with antimicrobial susceptibility profiles.耐喹诺酮淋病奈瑟菌：DNA 回旋酶 GyrA 亚基和拓扑异构酶 IV 的 ParC 亚基改变与抗菌药物敏感性谱的相关性
Antimicrob Agents Chemother. 1996 Apr;40(4):1020-3. doi: 10.1128/AAC.40.4.1020.
3
Quinolone resistance mutations in topoisomerase IV: relationship to the flqA locus and genetic evidence that topoisomerase IV is the primary target and DNA gyrase is the secondary target of fluoroquinolones in Staphylococcus aureus.拓扑异构酶IV中的喹诺酮耐药性突变：与flqA位点的关系以及金黄色葡萄球菌中拓扑异构酶IV是氟喹诺酮类药物的主要靶点而DNA回旋酶是次要靶点的遗传学证据。
Antimicrob Agents Chemother. 1996 Aug;40(8):1881-8. doi: 10.1128/AAC.40.8.1881.
4
Alterations in the DNA topoisomerase IV grlA gene responsible for quinolone resistance in Staphylococcus aureus.负责金黄色葡萄球菌喹诺酮耐药性的DNA拓扑异构酶IV grlA基因的改变。
Antimicrob Agents Chemother. 1996 May;40(5):1157-63. doi: 10.1128/AAC.40.5.1157.
5
Topoisomerase IV is a target of quinolones in Escherichia coli.拓扑异构酶IV是喹诺酮类药物在大肠杆菌中的作用靶点。
Proc Natl Acad Sci U S A. 1995 Dec 5;92(25):11801-5. doi: 10.1073/pnas.92.25.11801.
6
Mechanism of action of quinolones against Escherichia coli DNA gyrase.喹诺酮类药物对大肠杆菌DNA旋转酶的作用机制。
Antimicrob Agents Chemother. 1993 Apr;37(4):839-45. doi: 10.1128/AAC.37.4.839.
7
Mutations in the gyrA gene of a highly fluoroquinolone-resistant clinical isolate of Escherichia coli.一株高度耐氟喹诺酮的大肠杆菌临床分离株gyrA基因中的突变。
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9
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Mol Microbiol. 1994 Oct;14(2):371-80. doi: 10.1111/j.1365-2958.1994.tb01297.x.
10
DNA gyrase mutations in quinolone-resistant clinical isolates of Neisseria gonorrhoeae.淋病奈瑟菌喹诺酮耐药临床分离株中的DNA回旋酶突变
Antimicrob Agents Chemother. 1995 Feb;39(2):561-3. doi: 10.1128/AAC.39.2.561.
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