Andrada J A, von der Walde F, Hoschoian J C, Comini E, Mancini E
Andrologia. 1977 Jul-Sep;9(3):207-15. doi: 10.1111/j.1439-0272.1977.tb01289.x.
Seventy patients with mumps orchitis were investigated. Serological tests for antitesticular antibodies, using four different techniques showed positive results in 25 patients. Antivirus antibodies were detected and they reached higher values during the remission period of acute cases. Delayed hypersensitivity was studied by means of skin tests using homologous antigenic material. Several patients gave definite positive reactions. Testicular biopsies performed in some patients showed a histological picture similar to that obtained in experimental human or animal auto- or iso-sensitization. All patients in whom testicular damage was present also showed positive skin tests, ascertained by histology of the site of reaction, but none of them exhibited circulating antibodies in meaningful titers. The skin hypersensitivity suggest some correlation between this type of reaction and the development of the testicular lesions as shown in several other diseases in which an immune mechanism could be involved.
对70例流行性腮腺炎性睾丸炎患者进行了调查。采用四种不同技术进行的抗睾丸抗体血清学检测显示，25例患者呈阳性结果。检测到抗病毒抗体，且在急性病例的缓解期其值更高。通过使用同源抗原物质的皮肤试验研究迟发型超敏反应。数名患者呈明确的阳性反应。部分患者进行的睾丸活检显示出与在实验性人类或动物自身或同种致敏中获得的相似组织学图像。通过反应部位的组织学确定，所有存在睾丸损伤的患者皮肤试验也呈阳性，但他们均未表现出有意义滴度的循环抗体。皮肤超敏反应表明，这种类型的反应与睾丸病变的发展之间存在某种关联，正如在其他一些可能涉及免疫机制的疾病中所显示的那样。
