Liu K, Stamler J, Moss D, Garside D, Persky V, Soltero I
Lancet. 1979 Oct 13;2(8146):782-5. doi: 10.1016/s0140-6736(79)92126-3.
It has been suggested that high fat, high cholesterol, and low fibre intakes play a role in the causation of colon cancer, but since they are highly intercorrelated, it is difficult to determine which (if any) variable is truly related to colon cancer. Food disappearance data for 1954--65 and mortality data for 1967--73 from 20 industrialised countries were used to assess which variables are independently related to colon cancer. Simple correlation analysis indicated that intake of total fat, saturated fat, monounsaturated fat, cholesterol, and fibres are each highly correlated with mortality-rate for colon cancer. The partial correlation of dietary cholesterol with colon cancer remains highly significant when fat or fibre is controlled. However, the partial correlations of fat or of fibre iwth colon cancer are no longer significant when cholesterol is controlled. Cross-classification showed a highly signficant main effect for cholesterol, but nor for fat or fibre. The findings support the possibility of a causal relationship between cholesterol intake and colon cancer.
有人认为，高脂肪、高胆固醇和低纤维的摄入在结肠癌的病因中起作用，但由于它们之间高度相关，很难确定哪个（如果有的话）变量与结肠癌真正相关。利用20个工业化国家1954 - 1965年的食物消失数据和1967 - 1973年的死亡率数据来评估哪些变量与结肠癌独立相关。简单相关分析表明，总脂肪、饱和脂肪、单不饱和脂肪、胆固醇和纤维的摄入量均与结肠癌死亡率高度相关。当控制脂肪或纤维时，膳食胆固醇与结肠癌的偏相关仍然高度显著。然而，当控制胆固醇时，脂肪或纤维与结肠癌的偏相关不再显著。交叉分类显示胆固醇有高度显著的主效应，但脂肪或纤维没有。这些发现支持了胆固醇摄入与结肠癌之间存在因果关系的可能性。
