Shimizu M, Osada K, Okamoto H
Department of Transfusion Medicine, Tokyo Women's Medical College, Japan.
Vox Sang. 1997;72(2):76-8. doi: 10.1046/j.1423-0410.1997.7220076.x.
Hepatitis-causing viral agents other than those designated A to E are being reported. Their epidemiology, modes of transmission, and infectivity are not yet clear, although they may be transmitted by transfusion.
Thirty five patients underwent open-heart surgery, receiving an average of 10.2 +/- 10.8 (range 1 to 35) units of blood. The patients were investigated postoperatively for the RNA of the putative non-A-to-E hepatitis virus designated as GB virus C (GBV-C).
Four patients (12%) acquired GBV-C RNA in the serum within 2 to 4 weeks after the operation. GBV-C RNA was detected in at least one of the blood units received by three patients, all of whose units were available for testing, with a sequence in the nonstructural 3 region identical to that from the corresponding patient. Three patients developed elevated alanine aminotransferase levels which persisted for two weeks or longer in two of them.
GBV-C is transmissible by transfusion and can induce elevated transaminase levels.
除了已命名的A至E型肝炎病毒外，其他导致肝炎的病毒因子也有报道。尽管它们可能通过输血传播，但其流行病学、传播方式和传染性尚不清楚。
35例患者接受了心脏直视手术，平均输注了10.2±10.8（范围1至35）单位血液。术后对患者进行了检测，以寻找被称为GB病毒C（GBV-C）的假定非A至E型肝炎病毒的RNA。
4例患者（12%）在术后2至4周内血清中检测到GBV-C RNA。在3例患者输注的至少一个血液单位中检测到GBV-C RNA，这3例患者输注的所有血液单位均可供检测，其中非结构3区的序列与相应患者的序列相同。3例患者出现丙氨酸转氨酶水平升高，其中2例持续两周或更长时间。
GBV-C可通过输血传播，并可导致转氨酶水平升高。
