Park K K, Surh Y J
College of Dentistry, Yonsei University, Seoul, South Korea.
Cancer Lett. 1997 Mar 19;114(1-2):183-4. doi: 10.1016/s0304-3835(97)04657-0.
Capsaicin (trans-8-methyl-N-vanillyl-6-nonenamide) is a principal pungent ingredient of hot red peppers. There are some controversies with regard to its inherent tumorigenicity and mutagenicity. The present work was undertaken to assess tumor initiating and promotional effects of capsaicin in a two-stage mouse skin carcinogenesis model. A single topical application of capsaicin (10 micromol) followed by twice-weekly applications of 12-O-tetradecanoylphorbol-13-acetate onto shaven backs of female ICR mice resulted in no significant increases in incidence and multiplicity of skin tumors, compared with the solvent-pretreated control animals. Repeated topical applications of capsaicin alone failed to promote 7,12-dimethylbenz[a]anthracene-initiated mouse skin tumorigenesis, but moderately inhibited the papilloma formation when given prior to each topical dose of phorbol ester.
辣椒素（反式-8-甲基-N-香草基-6-壬烯酰胺）是红辣椒的主要辛辣成分。关于其固有的致瘤性和致突变性存在一些争议。本研究旨在评估辣椒素在两阶段小鼠皮肤致癌模型中的肿瘤起始和促进作用。与溶剂预处理的对照动物相比，在雌性ICR小鼠剃毛的背部单次局部应用辣椒素（10微摩尔），随后每周两次应用12-O-十四烷酰佛波醇-13-乙酸酯，皮肤肿瘤的发生率和多发性没有显著增加。单独重复局部应用辣椒素未能促进7,12-二甲基苯并[a]蒽引发的小鼠皮肤肿瘤发生，但在每次局部给予佛波酯之前给予时，可适度抑制乳头状瘤的形成。
