Lacey C J, Murphy M E, Sanderson M J, Monteiro E F, Vail A, Schorah C J
Department of Genitourinary Medicine, General Infirmary at Leeds, UK.
Int J STD AIDS. 1996 Nov-Dec;7(7):485-9. doi: 10.1258/0956462961918554.
We measured plasma levels of all the antioxidant-micronutrients in subjects with HIV infection and controls. Plasma levels of all the carotenoids, including lutein, cryptoxanthin, lycopene, alpha-carotene and beta-carotene as well as vitamins A, C and E and cholesterol were assayed in 35 subjects with HIV infection and 38 controls. We found a significant depletion of all the carotenoids (P < 0.001) and vitamin C (P < 0.01) and cholesterol (P < 0.001) but not vitamins A or E in HIV-infected subjects. Further analysis of the HIV-infected subjects revealed that plasma levels of 4 of the groups of carotenoids and cholesterol were correlated with CD4 count but that beta-carotene and vitamins A, C and E were not. These results are reviewed in the light of the published literature and we conclude that these abnormalities of antioxidant-micronutrients are likely to reflect a metabolic phenomenon associated with HIV infection. However, an additional contribution to these deficiencies from malabsorption later in HIV disease cannot be ruled out.
我们检测了感染HIV的受试者及对照组中所有抗氧化微量营养素的血浆水平。对35名感染HIV的受试者和38名对照组人员的血浆中所有类胡萝卜素（包括叶黄素、隐黄质、番茄红素、α-胡萝卜素和β-胡萝卜素）、维生素A、C、E以及胆固醇水平进行了检测。我们发现，感染HIV的受试者中所有类胡萝卜素（P < 0.001）、维生素C（P < 0.01）和胆固醇（P < 0.001）水平均显著降低，但维生素A和E水平未降低。对感染HIV的受试者的进一步分析显示，4种类胡萝卜素组和胆固醇的血浆水平与CD4细胞计数相关，但β-胡萝卜素以及维生素A、C和E与CD4细胞计数无关。我们根据已发表的文献对这些结果进行了综述，并得出结论：这些抗氧化微量营养素的异常情况可能反映了与HIV感染相关的一种代谢现象。然而，不能排除HIV疾病后期吸收不良对这些营养素缺乏的额外影响。
