Ghodratnama F, Riggio M P, Wray D
Infection and Immunity Research Group, University of Glasgow Dental School, UK.
J Oral Pathol Med. 1997 Apr;26(4):192-7. doi: 10.1111/j.1600-0714.1997.tb00457.x.
In the present study, the involvement of human herpesvirus 6 (HHV-6), human cytomegalovirus (HCMV) and varicella zoster virus (VZV) in the aetiology of recurrent aphthous stomatitis (RAS) was investigated using the polymerase chain reaction (PCR). Biopsies from 21 RAS patients were analysed, and 20 oral lichen planus (OLP) and 13 normal biopsies were tested as controls. HHV-6-DNA was detected in six of the RAS samples whereas VZV-DNA and HCMV-DNA were not detected in any RAS samples. In the OLP samples, four biopsies were positive for HHV-6-DNA and two were positive for HCMV-DNA. One sample from this group was positive for both HHV-6-DNA and HCMV-DNA. VZV-DNA was not found in any RAS or OLP biopsies. No viral DNA was present in any normal control biopsies. These results do not support an aetiological role for HCMV and VZV in RAS, although the possible involvement of HHV-6 cannot be excluded.
在本研究中，运用聚合酶链反应（PCR）对人类疱疹病毒6型（HHV-6）、人类巨细胞病毒（HCMV）和水痘带状疱疹病毒（VZV）在复发性阿弗他口炎（RAS）病因学中的作用进行了调查。对21例RAS患者的活检样本进行了分析，并将20例口腔扁平苔藓（OLP）活检样本和13例正常活检样本作为对照进行检测。在6份RAS样本中检测到了HHV-6-DNA，而在任何RAS样本中均未检测到VZV-DNA和HCMV-DNA。在OLP样本中，4份活检样本HHV-6-DNA呈阳性，2份HCMV-DNA呈阳性。该组中有1份样本HHV-6-DNA和HCMV-DNA均呈阳性。在任何RAS或OLP活检样本中均未发现VZV-DNA。在任何正常对照活检样本中均未检测到病毒DNA。这些结果不支持HCMV和VZV在RAS病因学中的作用，尽管不能排除HHV-6的可能参与。
