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一种感染新英格兰鹿蜱(达氏硬蜱)的新型蜱传脑炎样病毒。

A new tick-borne encephalitis-like virus infecting New England deer ticks, Ixodes dammini.

作者信息

Telford S R, Armstrong P M, Katavolos P, Foppa I, Garcia A S, Wilson M L, Spielman A

机构信息

Harvard School of Public Health, Boston, Massachusetts, USA.

出版信息

Emerg Infect Dis. 1997 Apr-Jun;3(2):165-70. doi: 10.3201/eid0302.970209.

DOI:10.3201/eid0302.970209
PMID:9204297
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2627606/
Abstract

To determine if eastern North American Ixodes dammini, like related ticks in Eurasia, maintain tick-borne encephalitis group viruses, we analyzed ticks collected from sites where the agent of Lyme disease is zoonotic. Two viral isolates were obtained by inoculating mice with homogenates from tick salivary glands. The virus, which was described by reverse transcriptase polymerase chain reaction and direct sequencing of the amplification products, was similar to, but distinct from, Powassan virus and is provisionally named "deer tick virus." Enzootic tick-borne encephalitis group viruses accompany the agents of Lyme disease, babesiosis, and granulocytic ehrlichiosis in a Holarctic assemblage of emergent deer tick pathogens.

摘要

为了确定北美东部的达氏硬蜱(Ixodes dammini)是否像欧亚大陆的相关蜱虫那样携带着蜱传脑炎病毒群病毒,我们分析了从莱姆病病原体为人畜共患病原体的地点采集的蜱虫。通过用蜱虫唾液腺匀浆接种小鼠,获得了两种病毒分离株。通过逆转录聚合酶链反应和对扩增产物进行直接测序来描述的这种病毒,与波瓦桑病毒相似但又不同,暂命名为“鹿蜱病毒”。在一个全北区新出现的鹿蜱病原体组合中,蜱传脑炎病毒群病毒与莱姆病、巴贝斯虫病和粒细胞埃立克体病的病原体共存。

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本文引用的文献

1
Virus meningo-encephalitis in Austria. II. Clinical features, pathology, and diagnosis.奥地利的病毒性脑膜脑炎。II. 临床特征、病理学及诊断
Bull World Health Organ. 1955;12(4):535-64.
2
On the absence of desoxyribonucleic acid from some chemically-induced cytoplasmic and intranuclear inclusions, with reference to a special type of false positive staining by Feulgen's nuclear technique.关于某些化学诱导的细胞质和核内包涵体中脱氧核糖核酸的缺失,以及Feulgen核技术的一种特殊类型的假阳性染色
J Pathol Bacteriol. 1954 Jul;68(1):159-64. doi: 10.1002/path.1700680120.
3
Experimental transmission of Powassan virus (Flaviviridae) by Ixodes scapularis ticks (Acari:Ixodidae).肩突硬蜱(蜱螨亚纲:硬蜱科)传播波瓦桑病毒(黄病毒科)的实验研究
Am J Trop Med Hyg. 1996 Nov;55(5):536-46. doi: 10.4269/ajtmh.1996.55.536.
4
Perpetuation of the agent of human granulocytic ehrlichiosis in a deer tick-rodent cycle.人粒细胞埃立克体病病原体在鹿蜱-啮齿动物循环中的持续存在。
Proc Natl Acad Sci U S A. 1996 Jun 11;93(12):6209-14. doi: 10.1073/pnas.93.12.6209.
5
Conspecificity of the ticks Ixodes scapularis and I. dammini (Acari: Ixodidae).肩突硬蜱和达氏硬蜱(蜱螨亚纲:硬蜱科)的同种性。
J Med Entomol. 1993 Jan;30(1):54-63. doi: 10.1093/jmedent/30.1.54.
6
Detection of Borrelia burgdorferi DNA in museum specimens of Peromyscus leucopus.在白足鼠博物馆标本中检测伯氏疏螺旋体DNA。
J Infect Dis. 1994 Oct;170(4):1027-32. doi: 10.1093/infdis/170.4.1027.
7
Ecology of Ixodes dammini-borne human babesiosis and Lyme disease.达氏硬蜱传播的人类巴贝斯虫病和莱姆病的生态学
Annu Rev Entomol. 1985;30:439-60. doi: 10.1146/annurev.en.30.010185.002255.
8
Reservoir competence of white-footed mice for Lyme disease spirochetes.白足鼠对莱姆病螺旋体的储存宿主能力。
Am J Trop Med Hyg. 1987 Jan;36(1):92-6. doi: 10.4269/ajtmh.1987.36.92.
9
A novel mode of arbovirus transmission involving a nonviremic host.一种涉及非病毒血症宿主的虫媒病毒传播新方式。
Science. 1987 Aug 14;237(4816):775-7. doi: 10.1126/science.3616608.
10
Genome sequence of tick-borne encephalitis virus (Western subtype) and comparative analysis of nonstructural proteins with other flaviviruses.蜱传脑炎病毒(西方亚型)基因组序列及与其他黄病毒非结构蛋白的比较分析。
Virology. 1989 Nov;173(1):291-301. doi: 10.1016/0042-6822(89)90246-8.