Jay M, Ascher M S, Chomel B B, Madon M, Sesline D, Enge B A, Hjelle B, Ksiazek T G, Rollin P E, Kass P H, Reilly K
California Department of Health Services, Sacramento, USA.
Emerg Infect Dis. 1997 Apr-Jun;3(2):183-90. doi: 10.3201/eid0302.970213.
A total of 4,626 mammals were serologically tested for antibodies to Sin Nombre virus. All nonrodent species were antibody negative. Among wild rodents, antibody prevalence was 8.5% in murids, 1.4% in heteromyids, and < 0.1% in sciurids. Of 1,921 Peromyscus maniculatus (deer mice), 226 (11.8%) were antibody positive, including one collected in 1975. The highest antibody prevalence (71.4% of 35) was found among P. maniculatus on Santa Cruz Island, off the southern California coast. Prevalence of antibodies among deer mice trapped near sites of human cases (26.8% of 164) was significantly higher than that of mice from other sites (odds ratio = 4.5; 95% confidence interval = 1.7, 11.6). Antibody prevalence increased with rising elevation (> 1,200 meters) and correlated with a spatial cluster of hantavirus pulmonary syndrome cases in the Sierra Nevada.
总共对4626只哺乳动物进行了血清学检测，以检测其是否含有针对辛诺柏病毒的抗体。所有非啮齿类动物的抗体检测均为阴性。在野生啮齿动物中，家鼠科动物的抗体阳性率为8.5%，更格卢鼠科动物为1.4%，松鼠科动物则小于0.1%。在1921只白足鼠（鹿鼠）中，有226只（11.8%）抗体呈阳性，其中包括1975年采集的一只。在南加利福尼亚海岸外的圣克鲁斯岛上的白足鼠中，抗体阳性率最高（35只中有71.4%）。在人类病例附近捕获的鹿鼠中，抗体阳性率（164只中有26.8%）显著高于其他地点捕获的小鼠（优势比=4.5；95%置信区间=1.7, 11.6）。抗体阳性率随海拔升高（>1200米）而增加，并且与内华达山脉汉坦病毒肺综合征病例的空间聚集相关。
