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1
Effect of granulocyte colony-stimulating factor on the candidacidal activity of polymorphonuclear neutrophils and their collaboration with fluconazole.粒细胞集落刺激因子对多形核中性粒细胞杀念珠菌活性及其与氟康唑协同作用的影响。
Antimicrob Agents Chemother. 1997 Jul;41(7):1575-8. doi: 10.1128/AAC.41.7.1575.
2
Activity of voriconazole, a new triazole, combined with neutrophils or monocytes against Candida albicans: effect of granulocyte colony-stimulating factor and granulocyte-macrophage colony-stimulating factor.新型三唑类药物伏立康唑与中性粒细胞或单核细胞联合抗白色念珠菌的活性：粒细胞集落刺激因子和粒细胞-巨噬细胞集落刺激因子的作用
Antimicrob Agents Chemother. 1998 Apr;42(4):907-10. doi: 10.1128/AAC.42.4.907.
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Effect of granulocyte-macrophage colony-stimulating factor on candidacidal activity of neutrophils, monocytes or monocyte-derived macrophages and synergy with fluconazole.粒细胞巨噬细胞集落刺激因子对中性粒细胞、单核细胞或单核细胞衍生巨噬细胞杀念珠菌活性的影响以及与氟康唑的协同作用。
J Med Microbiol. 1998 Apr;47(4):359-63. doi: 10.1099/00222615-47-4-359.
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Effects of interferon-γ and granulocyte colony-stimulating factor on antifungal activity of human polymorphonuclear neutrophils against Candida albicans grown as biofilms or planktonic cells.γ-干扰素和粒细胞集落刺激因子对人多形核白细胞抗白色念珠菌生物膜和浮游细胞的抗真菌活性的影响。
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Effects of granulocyte colony-stimulating factor and interferon-gamma on antifungal activity of human polymorphonuclear neutrophils against pseudohyphae of different medically important Candida species.粒细胞集落刺激因子和γ干扰素对人多形核中性粒细胞抗不同医学重要念珠菌属假菌丝的抗真菌活性的影响。
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4
Activity of voriconazole, a new triazole, combined with neutrophils or monocytes against Candida albicans: effect of granulocyte colony-stimulating factor and granulocyte-macrophage colony-stimulating factor.新型三唑类药物伏立康唑与中性粒细胞或单核细胞联合抗白色念珠菌的活性：粒细胞集落刺激因子和粒细胞-巨噬细胞集落刺激因子的作用
Antimicrob Agents Chemother. 1998 Apr;42(4):907-10. doi: 10.1128/AAC.42.4.907.

本文引用的文献

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Synergy of human neutrophils with fluconazole in killing Candida species.人类中性粒细胞与氟康唑协同杀灭念珠菌属。
Mycopathologia. 1996;134(3):115-20. doi: 10.1007/BF00436717.
2
Role of extended culture time on synergy of fluconazole and human monocyte-derived macrophages in clearing Candida albicans.延长培养时间对氟康唑与人类单核细胞衍生巨噬细胞清除白色念珠菌协同作用的影响
J Infect Dis. 1996 Oct;174(4):888-90. doi: 10.1093/infdis/174.4.888.
3
A randomized controlled phase III trial of recombinant human granulocyte colony-stimulating factor (filgrastim) for treatment of severe chronic neutropenia.一项关于重组人粒细胞集落刺激因子（非格司亭）治疗严重慢性中性粒细胞减少症的随机对照III期试验。
Blood. 1993 May 15;81(10):2496-502.
4
Multicenter evaluation of a broth macrodilution antifungal susceptibility test for yeasts.酵母肉汤大稀释法抗真菌药敏试验的多中心评估
Antimicrob Agents Chemother. 1993 Jan;37(1):39-45. doi: 10.1128/AAC.37.1.39.
5
Synergy of fluconazole with human monocytes or monocyte-derived macrophages for killing of Candida species.氟康唑与人类单核细胞或单核细胞衍生巨噬细胞协同作用以杀灭念珠菌属。
J Infect Dis. 1995 Dec;172(6):1620-3. doi: 10.1093/infdis/172.6.1620.
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Beneficial effect of recombinant human granulocyte colony-stimulating factor on fungicidal activity of polymorphonuclear leukocytes from patients with AIDS.重组人粒细胞集落刺激因子对艾滋病患者多形核白细胞杀菌活性的有益作用。
J Infect Dis. 1995 Jun;171(6):1448-54. doi: 10.1093/infdis/171.6.1448.
7
Effect of granulocyte colony stimulating factor on neutropenia induced by cytotoxic chemotherapy.粒细胞集落刺激因子对细胞毒性化疗所致中性粒细胞减少的影响。
Lancet. 1988 Mar 26;1(8587):667-72. doi: 10.1016/s0140-6736(88)91475-4.
8
Phase I/II study of recombinant human granulocyte colony-stimulating factor in patients receiving intensive chemotherapy for small cell lung cancer.重组人粒细胞集落刺激因子用于小细胞肺癌强化化疗患者的Ⅰ/Ⅱ期研究
Br J Cancer. 1987 Dec;56(6):809-13. doi: 10.1038/bjc.1987.295.
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High-frequency switching in Candida strains isolated from vaginitis patients.从阴道炎患者分离出的念珠菌菌株中的高频开关
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10
The effect of recombinant human colony-stimulating factors on hematopoietic reconstitution following autologous bone marrow transplantation.重组人集落刺激因子对自体骨髓移植后造血重建的影响。
Semin Hematol. 1989 Apr;26(2 Suppl 2):18-23.

粒细胞集落刺激因子对多形核中性粒细胞杀念珠菌活性及其与氟康唑协同作用的影响。

Effect of granulocyte colony-stimulating factor on the candidacidal activity of polymorphonuclear neutrophils and their collaboration with fluconazole.

作者信息

Natarajan U, Brummer E, Stevens D A

机构信息

Department of Medicine, Santa Clara Valley Medical Center, and California Institute for Medical Research, San Jose 95128-2699, USA.

出版信息

Antimicrob Agents Chemother. 1997 Jul;41(7):1575-8. doi: 10.1128/AAC.41.7.1575.

DOI:10.1128/AAC.41.7.1575
PMID:9210688
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC163962/
Abstract

The effect of granulocyte colony-stimulating factor (GCSF) treatment of polymorphonuclear neutrophils (PMN) in vitro was studied with respect to their candidacidal activity. The candidacidal activity of PMN was found to be significantly increased when they were pretreated with GCSF. Fluconazole (1 microg/ml) was found to be highly fungistatic (90%) for Candida albicans Sh27 and collaborated with PMN for significantly increased killing. Collaborative killing by PMN significantly increased when they were treated with GCSF before and after fungal exposure. The enhancing activities of GCSF required optimization of the GCSF dose and were thus inoculum and strain dependent.

摘要

研究了粒细胞集落刺激因子（GCSF）体外处理多形核中性粒细胞（PMN）对其杀念珠菌活性的影响。发现用GCSF预处理PMN后，其杀念珠菌活性显著增加。发现氟康唑（1微克/毫升）对白色念珠菌Sh27具有高度抑菌作用（90%），并与PMN协同作用，显著增强杀菌效果。当PMN在真菌暴露前后用GCSF处理时，其协同杀菌作用显著增强。GCSF的增强活性需要优化GCSF剂量，因此其增强活性取决于接种量和菌株。