Miyachi S, Hikosaka O, Miyashita K, Kárádi Z, Rand M K
Laboratory of Neural Control, National Institute for Physiological Sciences, Okazaki, Japan.
Exp Brain Res. 1997 Jun;115(1):1-5. doi: 10.1007/pl00005669.
To study the role of the basal ganglia in learning of sequential movements, we trained two monkeys to perform a sequential button-press task (2x5 task). This task enabled us to examine the process of learning new sequences as well as the execution of well-learned sequences repeatedly. We injected muscimol (a GABA agonist) into different parts of the striatum to inactivate the local neural activity reversibly. The learning of new sequences became deficient after injections in the anterior caudate and putamen, but not the middle-posterior putamen. The execution of well-learned sequences was disrupted after injections in the middle-posterior putamen and, less severely, after injections in the anterior caudate/putamen. These results suggest that the anterior and posterior portions of the striatum participate in different aspects of learning of sequential movements.
为研究基底神经节在序列运动学习中的作用，我们训练了两只猴子执行序列按键任务（2x5任务）。该任务使我们能够检查学习新序列的过程以及反复执行已熟练掌握序列的情况。我们将蝇蕈醇（一种GABA激动剂）注射到纹状体的不同部位，以可逆地使局部神经活动失活。在前尾状核和壳核注射后，新序列的学习出现缺陷，但在中后壳核注射后则没有。在中后壳核注射后，已熟练掌握序列的执行受到干扰，在前尾状核/壳核注射后干扰程度较轻。这些结果表明，纹状体的前部和后部参与序列运动学习的不同方面。
