Ahlm C, Alexeyev O A, Elgh F, Aava B, Wadell G, Tarnvik A, Juto P, Palo T
Department of Infectious Diseases, Umea University, Umea, Sweden.
Am J Trop Med Hyg. 1997 Jun;56(6):674-8. doi: 10.4269/ajtmh.1997.56.674.
Puumala virus, the causative agent of nephropathia epidemica (NE), occurs endemically in Europe and is spread mainly by the bank vole (Clethrionomys glareolus). In the vicinity of each of four households afflicted with NE, we studied rodents with regard to population density and prevalence of Puumala virus-specific antibodies. For each case area, a control area was randomly selected 10 km away, without regard to the presence of human settlement. During 6,000 trap nights, 328 rodents were caught, of which 299 were C. glareolus. The mean rodent densities of case and control areas were 6.6 and 3.7 animals per 100 trap nights (P < 0.001). The prevalence of serum antibodies was 15.9% in case areas compared with 5.6% in control areas (P < 0.05). In three of the case areas, where NE had occurred 3-10 weeks before trapping, the rodent density and seroprevalence were much higher than in the fourth area, where NE occurred 38 weeks before trapping. In conclusion, C. glareolus seropositive for Puumala virus occurred more frequently near households afflicted with NE than in control areas 10 km away.
普马拉病毒是流行性肾病（NE）的病原体，在欧洲呈地方性流行，主要通过棕背鼠平（黄毛鼠平）传播。在4户感染NE的家庭附近，我们对啮齿动物的种群密度和普马拉病毒特异性抗体的流行情况进行了研究。对于每个病例区域，在不考虑人类居住情况的前提下，随机选择10公里外的一个区域作为对照区域。在6000个诱捕夜期间，共捕获328只啮齿动物，其中299只为棕背鼠平。病例区域和对照区域的啮齿动物平均密度分别为每100个诱捕夜6.6只和3.7只动物（P<0.001）。病例区域血清抗体的流行率为15.9%，而对照区域为5.6%（P<0.05）。在诱捕前3至10周发生NE的3个病例区域，啮齿动物密度和血清阳性率远高于诱捕前38周发生NE的第4个区域。总之，感染普马拉病毒血清呈阳性的棕背鼠平在感染NE的家庭附近比在10公里外的对照区域更常见。
