Freeman J A, Langdon D W, Hobart J C, Thompson A J
Institute of Neurology, London, UK.
Ann Neurol. 1997 Aug;42(2):236-44. doi: 10.1002/ana.410420216.
One of the primary aims of rehabilitation for patients with multiple sclerosis (MS) is to reduce their levels of disability and handicap, yet little systematic research into the outcomes of this intervention has been undertaken. This stratified, randomized, wait-list controlled study evaluated the effectiveness of a short period of multidisciplinary inpatient rehabilitation in people with MS. Sixty-six patients in the progressive phase of the disease were assessed at 0 and 6 weeks with validated measures of impairment (Expanded Disability Status Scale and Functional Systems), disability (Functional Independence Measure), and handicap (London Handicap Scale). Both groups were comparable in terms of age, sex, disease duration and severity, disability, and handicap. At the end of 6 weeks, although the level of impairment in both groups remained the same, those who participated in a short period of inpatient rehabilitation (average of 25 days) significantly improved their level of disability and handicap compared with those in the wait-list control group. Despite unchanging impairment, inpatient rehabilitation resulted in reduced disability and handicap in patients with progressive MS.
多发性硬化症（MS）患者康复的主要目标之一是降低其残疾和残障程度，但针对这种干预措施的效果却鲜有系统研究。这项分层、随机、等待列表对照研究评估了短期多学科住院康复对MS患者的有效性。采用经过验证的损伤（扩展残疾状态量表和功能系统）、残疾（功能独立性测量）和残障（伦敦残障量表）测量方法，在第0周和第6周对66例处于疾病进展期的患者进行了评估。两组在年龄、性别、病程和严重程度、残疾和残障方面具有可比性。在6周结束时，尽管两组的损伤程度保持不变，但与等待列表对照组相比，参与短期住院康复（平均25天）的患者的残疾和残障程度有显著改善。尽管损伤程度没有变化，但住院康复使进展型MS患者的残疾和残障程度有所降低。
