SSU1编码一种质膜蛋白，该蛋白在酿酒酵母中赋予亚硫酸盐耐受性的蛋白质网络中起核心作用。
SSU1 encodes a plasma membrane protein with a central role in a network of proteins conferring sulfite tolerance in Saccharomyces cerevisiae.
作者信息
Avram D, Bakalinsky A T
机构信息
Genetics Program, Oregon State University, Corvallis 97331-6602, USA.
出版信息
J Bacteriol. 1997 Sep;179(18):5971-4. doi: 10.1128/jb.179.18.5971-5974.1997.
Abstract
The Saccharomyces cerevisiae SSU1 gene was isolated based on its ability to complement a mutation causing sensitivity to sulfite, a methionine intermediate. SSU1 encodes a deduced protein of 458 amino acids containing 9 or 10 membrane-spanning domains but has no significant similarity to other proteins in public databases. An Ssu1p-GEP fusion protein was localized to the plasma membrane. Multicopy suppression analysis, undertaken to explore relationships among genes previously implicated in sulfite metabolism, suggests a regulatory pathway in which SSU1 acts downstream of FZF1 and SSU3, which in turn act downstream of GRR1.
摘要
酿酒酵母的SSU1基因是根据其对亚硫酸盐（一种蛋氨酸中间体）敏感的突变体的互补能力而分离得到的。SSU1编码一个推导的含458个氨基酸的蛋白质，该蛋白质含有9或10个跨膜结构域，但与公共数据库中的其他蛋白质没有显著相似性。Ssu1p-GEP融合蛋白定位于质膜。为了探索先前涉及亚硫酸盐代谢的基因之间的关系而进行的多拷贝抑制分析表明，存在一条调控途径，其中SSU1在FZF1和SSU3的下游起作用，而FZF1和SSU3又在GRR1的下游起作用。
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本文引用的文献
1
Multicopy FZF1 (SUL1) suppresses the sulfite sensitivity but not the glucose derepression or aberrant cell morphology of a grr1 mutant of Saccharomyces cerevisiae.多拷贝FZF1（SUL1）可抑制酿酒酵母grr1突变体对亚硫酸盐的敏感性，但不能抑制其对葡萄糖的去阻遏作用或异常细胞形态。
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The COT2 gene is required for glucose-dependent divalent cation transport in Saccharomyces cerevisiae.COT2基因是酿酒酵母中葡萄糖依赖性二价阳离子转运所必需的。
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