Guízar-Vázquez J, Saint-Martin F P, Rostenberg I, Suárez P E, Armendares S
Am J Hum Genet. 1977 Nov;29(6):571-4.
The IgM serum level was determined in the members of 29 healthy families. The IgM mean concentrations between fathers and mothers and between sons and daughters were significantly different (P less than .01), with higher serum IgM levels in females than in males. Simple linear regression analysis was done for the following intrafamilial combinations: son-father, daughter-father, son-mother, and daughter-mother. Significant correlation coefficients (P less than .05) were obtained in all four combinations, which does not support the X-linked gene hypothesis (i.e., that the X chromosome carries quantitative genes for immunoglobulin M). An alternative explanation for the differences between sexes for IgM serum concentration is considered.
对29个健康家庭的成员测定了血清IgM水平。父亲与母亲之间以及儿子与女儿之间的IgM平均浓度存在显著差异（P<0.01），女性血清IgM水平高于男性。对以下家庭内部组合进行了简单线性回归分析：儿子-父亲、女儿-父亲、儿子-母亲和女儿-母亲。在所有四种组合中均获得了显著的相关系数（P<0.05），这并不支持X连锁基因假说（即X染色体携带免疫球蛋白M的定量基因）。文中考虑了对IgM血清浓度性别差异的另一种解释。
