自然感染小鼠对蜱传伯氏疏螺旋体再感染的免疫持续时间。
Duration of immunity to reinfection with tick-transmitted Borrelia burgdorferi in naturally infected mice.
作者信息
Piesman J, Dolan M C, Happ C M, Luft B J, Rooney S E, Mather T N, Golde W T
机构信息
Division of Vector-Borne Infectious Diseases, Centers for Disease Control and Prevention, Fort Collins, Colorado 80522, USA.
出版信息
Infect Immun. 1997 Oct;65(10):4043-7. doi: 10.1128/iai.65.10.4043-4047.1997.
Abstract
The ability of naturally infected and cured mice to resist reinfection with tick-transmitted Borrelia burgdorferi was tested over a 1-year period. All of the mice were resistant to reinfection when they were challenged at 1.5 months after cure. The majority of animals were resistant to reinfection for up to 10.5 months after cure, but this resistance was lost at 1 year after cure. Both protected and unprotected animals showed a diverse array of antibodies on Western immunoblots. Protection was not associated with the killing of spirochetes in ticks, and naturally infected mice produced no antibodies to outer surface protein A (OSP A). The titers to whole Borrelia sonicate and OSP C, however, remained high throughout the 1-year study period. The levels of borreliacidal antibodies were highest in the 1.5 month-after-cure group. Natural immunity to reinfection with B. burgdorferi is limited in time, is complex, and may involve both humoral and cellular components.
摘要
在1年的时间里，对自然感染并治愈的小鼠抵抗蜱传播的伯氏疏螺旋体再次感染的能力进行了测试。当所有小鼠在治愈后1.5个月受到攻击时，它们都对再次感染具有抵抗力。大多数动物在治愈后长达10.5个月对再次感染具有抵抗力，但这种抵抗力在治愈后1年丧失。在蛋白质免疫印迹法中，受保护和未受保护的动物均显示出多种抗体。保护作用与蜱中螺旋体的杀灭无关，并且自然感染的小鼠不会产生针对外表面蛋白A（OSP A）的抗体。然而，在整个1年的研究期间，针对全伯氏疏螺旋体超声裂解物和OSP C的滴度仍然很高。杀螺旋体抗体水平在治愈后1.5个月的组中最高。对伯氏疏螺旋体再次感染的天然免疫力在时间上是有限的，是复杂的，并且可能涉及体液和细胞成分。
相似文献
1
Duration of immunity to reinfection with tick-transmitted Borrelia burgdorferi in naturally infected mice.自然感染小鼠对蜱传伯氏疏螺旋体再感染的免疫持续时间。
Infect Immun. 1997 Oct;65(10):4043-7. doi: 10.1128/iai.65.10.4043-4047.1997.
2
Tick transmission of Borrelia burgdorferi to inbred strains of mice induces an antibody response to P39 but not to outer surface protein A.伯氏疏螺旋体通过蜱虫传播给近交系小鼠后，会诱导机体产生针对P39的抗体反应，但不会产生针对外表面蛋白A的抗体反应。
Infect Immun. 1994 Jun;62(6):2625-7. doi: 10.1128/iai.62.6.2625-2627.1994.
3
T helper cell priming of mice to Borrelia burgdorferi OspA leads to induction of protective antibodies following experimental but not tick-borne infection.用伯氏疏螺旋体OspA对小鼠进行辅助性T细胞致敏，在实验性感染而非蜱传播感染后可诱导产生保护性抗体。
Eur J Immunol. 1997 Nov;27(11):2942-7. doi: 10.1002/eji.1830271129.
4
Resistance to tick-borne spirochete challenge induced by Borrelia burgdorferi strains that differ in expression of outer surface proteins.对由外表面蛋白表达不同的伯氏疏螺旋体菌株引发的蜱传螺旋体攻击的抵抗力。
Infect Immun. 1996 Oct;64(10):4148-53. doi: 10.1128/iai.64.10.4148-4153.1996.
5
Antigenic and genetic heterogeneity of Borrelia burgdorferi populations transmitted by ticks.蜱传播的伯氏疏螺旋体种群的抗原性和基因异质性。
Proc Natl Acad Sci U S A. 2001 Jan 16;98(2):670-5. doi: 10.1073/pnas.98.2.670.
6
Vaccination of natural reservoir hosts with recombinant lipidated OspA induces a transmission-blocking immunity against Lyme disease spirochaetes associated with high levels of LA-2 equivalent antibodies.用重组脂化OspA对自然宿主进行疫苗接种可诱导针对莱姆病螺旋体的传播阻断免疫，该免疫与高水平的LA-2等效抗体相关。
Vaccine. 1997 Oct;15(15):1670-4. doi: 10.1016/s0264-410x(97)00086-8.
7
Differential efficacy of passive immunisation against infection by Lyme disease spirochaetes transmitted by partially fed vector ticks.针对部分饱血媒介蜱传播的莱姆病螺旋体感染进行被动免疫的差异疗效。
J Med Microbiol. 1998 Sep;47(9):773-9. doi: 10.1099/00222615-47-9-773.
8
Direct demonstration of antigenic substitution of Borrelia burgdorferi ex vivo: exploration of the paradox of the early immune response to outer surface proteins A and C in Lyme disease.伯氏疏螺旋体外抗原替代的直接证明：探索莱姆病中对外膜蛋白A和C早期免疫反应的悖论。
J Exp Med. 1996 Jan 1;183(1):261-9. doi: 10.1084/jem.183.1.261.
9
Inhibition of Borrelia burgdorferi-tick interactions in vivo by outer surface protein A antibody.外表面蛋白A抗体在体内对伯氏疏螺旋体与蜱相互作用的抑制作用。
J Immunol. 2001 Jun 15;166(12):7398-403. doi: 10.4049/jimmunol.166.12.7398.
10
Protection against tick-transmitted Lyme disease in dogs vaccinated with a multiantigenic vaccine.用多抗原疫苗接种的犬只对蜱传播莱姆病的防护作用。
Vaccine. 2001 Oct 12;20(1-2):181-93. doi: 10.1016/s0264-410x(01)00251-1.
引用本文的文献
1
Characterization and genomic analysis of the Lyme disease spirochete bacteriophage ϕBB-1.莱姆病螺旋体噬菌体 ϕBB-1 的特征描述和基因组分析。
PLoS Pathog. 2024 Apr 1;20(4):e1012122. doi: 10.1371/journal.ppat.1012122. eCollection 2024 Apr.
2
Characterization and genomic analysis of the Lyme disease spirochete bacteriophage ϕBB-1.莱姆病螺旋体噬菌体ϕBB - 1的特性及基因组分析
bioRxiv. 2024 Jan 13:2024.01.08.574763. doi: 10.1101/2024.01.08.574763.
3
Lyme Disease in Humans.人类莱姆病。
Curr Issues Mol Biol. 2021;42:333-384. doi: 10.21775/cimb.042.333. Epub 2020 Dec 11.
4
Immune Response to : Lessons from Lyme Disease Spirochetes.对莱姆病螺旋体的免疫反应：教训。
Curr Issues Mol Biol. 2021;42:145-190. doi: 10.21775/cimb.042.145. Epub 2020 Dec 8.
5
Maternal Antibodies Provide Bank Voles with Strain-Specific Protection against Infection by the Lyme Disease Pathogen.母体抗体赋予黑线姬鼠针对莱姆病病原体感染的菌株特异性保护。
Appl Environ Microbiol. 2019 Nov 14;85(23). doi: 10.1128/AEM.01887-19. Print 2019 Dec 1.
6
Infection history of the blood-meal host dictates pathogenic potential of the Lyme disease spirochete within the feeding tick vector.血液宿主的感染史决定了莱姆病螺旋体在吸血节肢动物媒介中的致病潜力。
PLoS Pathog. 2018 Apr 5;14(4):e1006959. doi: 10.1371/journal.ppat.1006959. eCollection 2018 Apr.
7
Manipulates Innate and Adaptive Immunity to Establish Persistence in Rodent Reservoir Hosts.操纵先天性和适应性免疫以在啮齿类动物宿主中建立持续性感染。
Front Immunol. 2017 Feb 20;8:116. doi: 10.3389/fimmu.2017.00116. eCollection 2017.
8
Suppression of Long-Lived Humoral Immunity Following Borrelia burgdorferi Infection.伯氏疏螺旋体感染后对长期存在的体液免疫的抑制
PLoS Pathog. 2015 Jul 2;11(7):e1004976. doi: 10.1371/journal.ppat.1004976. eCollection 2015 Jul.
9
CD4+ T cells promote antibody production but not sustained affinity maturation during Borrelia burgdorferi infection.在伯氏疏螺旋体感染期间，CD4 + T细胞促进抗体产生，但不促进持续的亲和力成熟。
Infect Immun. 2015 Jan;83(1):48-56. doi: 10.1128/IAI.02471-14. Epub 2014 Oct 13.
10
Co-feeding transmission in Lyme disease pathogens.莱姆病病原体的共传播现象
Parasitology. 2015 Feb;142(2):290-302. doi: 10.1017/S0031182014001486. Epub 2014 Oct 8.
本文引用的文献
1
Antibiotic treatment in mice infected with Japanese Borrelia garinii: efficacy of ceftriaxone for eradicating the infection induced by Ixodes persulcatus tick bites.
Microbiol Immunol. 1997;41(2):165-8. doi: 10.1111/j.1348-0421.1997.tb01182.x.
2
Persistence of Borrelia burgdorferi in experimentally infected dogs after antibiotic treatment.抗生素治疗后实验感染犬体内伯氏疏螺旋体的持续性。
J Clin Microbiol. 1997 Jan;35(1):111-6. doi: 10.1128/jcm.35.1.111-116.1997.
3
Outer surface protein C (OspC), but not P39, is a protective immunogen against a tick-transmitted Borrelia burgdorferi challenge: evidence for a conformational protective epitope in OspC.外表面蛋白C（OspC）而非P39是抵抗蜱传播的伯氏疏螺旋体攻击的保护性免疫原：OspC中存在构象性保护性表位的证据。
Infect Immun. 1996 Jun;64(6):2234-9. doi: 10.1128/iai.64.6.2234-2239.1996.
4
Borrelia burgdorferi OspA is an arthropod-specific transmission-blocking Lyme disease vaccine.伯氏疏螺旋体OspA是一种针对节肢动物的、可阻断传播的莱姆病疫苗。
J Exp Med. 1996 Jan 1;183(1):271-5. doi: 10.1084/jem.183.1.271.
5
Mode of inoculation of the Lyme disease agent Borrelia burgdorferi influences infection and immune responses in inbred strains of mice.莱姆病病原体伯氏疏螺旋体的接种方式会影响近交系小鼠的感染和免疫反应。
J Infect Dis. 1993 Apr;167(4):971-5. doi: 10.1093/infdis/167.4.971.
6
Standard system for infecting ticks (Acari: Ixodidae) with the Lyme disease spirochete, Borrelia burgdorferi.用莱姆病螺旋体伯氏疏螺旋体感染蜱虫（蜱螨亚纲：硬蜱科）的标准系统。
J Med Entomol. 1993 Jan;30(1):199-203. doi: 10.1093/jmedent/30.1.199.
7
The major histocompatibility complex-restricted response of recombinant inbred strains of mice to natural tick transmission of Borrelia burgdorferi.小鼠重组近交系对伯氏疏螺旋体自然蜱传播的主要组织相容性复合体限制反应。
J Exp Med. 1993 Jan 1;177(1):9-17. doi: 10.1084/jem.177.1.9.
8
Characterization of the borreliacidal antibody response to Borrelia burgdorferi in humans: a serodiagnostic test.人类对伯氏疏螺旋体的杀螺旋体抗体反应的特征：一项血清诊断试验。
J Infect Dis. 1993 Jan;167(1):158-64. doi: 10.1093/infdis/167.1.158.
9
Passive immunizing activity of sera from mice infected with Borrelia burgdorferi.感染伯氏疏螺旋体的小鼠血清的被动免疫活性。
Infect Immun. 1993 Nov;61(11):4696-702. doi: 10.1128/iai.61.11.4696-4702.1993.
10
Distinct patterns of protective antibodies are generated against Borrelia burgdorferi in mice experimentally inoculated with high and low doses of antigen.在实验中用高剂量和低剂量抗原接种的小鼠体内，针对伯氏疏螺旋体产生了不同模式的保护性抗体。
Immunol Lett. 1993 May;36(2):219-26. doi: 10.1016/0165-2478(93)90056-8.
Zotero 插件